Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | yeeV-yafW/CbtA-CbeA |
Location | 828473..829266 | Replicon | chromosome |
Accession | NZ_CP073719 | ||
Organism | Escherichia coli strain CX12 |
Toxin (Protein)
Gene name | yeeV | Uniprot ID | S1EZ92 |
Locus tag | J6O05_RS04095 | Protein ID | WP_000854726.1 |
Coordinates | 828473..828850 (-) | Length | 126 a.a. |
Antitoxin (Protein)
Gene name | yafW | Uniprot ID | S1EBQ7 |
Locus tag | J6O05_RS04100 | Protein ID | WP_001548930.1 |
Coordinates | 828940..829266 (-) | Length | 109 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
J6O05_RS04075 (825213) | 825213..826361 | + | 1149 | WP_000287217.1 | DUF3322 domain-containing protein | - |
J6O05_RS04080 (826852) | 826852..827694 | - | 843 | WP_001548928.1 | DUF4942 domain-containing protein | - |
J6O05_RS04085 (827779) | 827779..827976 | - | 198 | WP_000839269.1 | DUF957 domain-containing protein | - |
J6O05_RS04090 (827988) | 827988..828476 | - | 489 | WP_001547769.1 | DUF5983 family protein | - |
J6O05_RS04095 (828473) | 828473..828850 | - | 378 | WP_000854726.1 | TA system toxin CbtA family protein | Toxin |
J6O05_RS04100 (828940) | 828940..829266 | - | 327 | WP_001548930.1 | type IV toxin-antitoxin system antitoxin YafW | Antitoxin |
J6O05_RS04105 (829285) | 829285..829506 | - | 222 | WP_000691994.1 | DUF987 domain-containing protein | - |
J6O05_RS04110 (829515) | 829515..829991 | - | 477 | WP_000811693.1 | RadC family protein | - |
J6O05_RS04115 (830007) | 830007..830465 | - | 459 | WP_000211838.1 | antirestriction protein | - |
J6O05_RS04120 (830563) | 830563..830802 | - | 240 | WP_000194654.1 | DUF905 family protein | - |
J6O05_RS04125 (830879) | 830879..831346 | - | 468 | WP_001548932.1 | protein YkfB | - |
J6O05_RS04130 (831370) | 831370..831813 | - | 444 | WP_000824224.1 | hypothetical protein | - |
J6O05_RS04135 (831813) | 831813..832049 | - | 237 | WP_001115854.1 | protein YpjK | - |
J6O05_RS04140 (832086) | 832086..832787 | - | 702 | WP_001548933.1 | WYL domain-containing protein | - |
J6O05_RS04145 (833005) | 833005..833826 | - | 822 | WP_001548934.1 | DUF932 domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14164.10 Da Isoelectric Point: 7.8045
>T200108 WP_000854726.1 NZ_CP073719:c828850-828473 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ
Download Length: 378 bp
>T200108 NZ_CP097711:1900402-1900653 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCCCTGGAGGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCTGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCCCTGGAGGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCTGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA
Antitoxin
Download Length: 109 a.a. Molecular weight: 12301.97 Da Isoelectric Point: 7.0273
>AT200108 WP_001548930.1 NZ_CP073719:c829266-828940 [Escherichia coli]
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFIRQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTFGSCGYVYLAVYPTPETKK
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFIRQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTFGSCGYVYLAVYPTPETKK
Download Length: 327 bp
>AT200108 NZ_CP097711:1900650-1900904 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCAGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCAGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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