Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4024540..4025056 Replicon chromosome
Accession NZ_CP073715
Organism Salmonella enterica subsp. enterica serovar Bovismorbificans strain 2020LSAL11867

Toxin (Protein)


Gene name relE Uniprot ID A0A5I6CHB9
Locus tag KCG42_RS19460 Protein ID WP_000220581.1
Coordinates 4024540..4024824 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag KCG42_RS19465 Protein ID WP_000212724.1
Coordinates 4024814..4025056 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KCG42_RS19445 (4019656) 4019656..4021308 + 1653 WP_000155045.1 alpha,alpha-phosphotrehalase -
KCG42_RS19450 (4021717) 4021717..4023855 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
KCG42_RS19455 (4024072) 4024072..4024536 + 465 WP_024792584.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KCG42_RS19460 (4024540) 4024540..4024824 - 285 WP_000220581.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KCG42_RS19465 (4024814) 4024814..4025056 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KCG42_RS19470 (4025134) 4025134..4027047 - 1914 WP_024792585.1 BglG family transcription antiterminator -
KCG42_RS19475 (4027064) 4027064..4027804 - 741 WP_000779252.1 KDGP aldolase family protein -
KCG42_RS19480 (4027801) 4027801..4028919 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
KCG42_RS19485 (4028903) 4028903..4030036 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10868.70 Da        Isoelectric Point: 10.0482

>T200065 WP_000220581.1 NZ_CP073715:c4024824-4024540 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T200065 NZ_CP097697:355806-356153 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT200065 WP_000212724.1 NZ_CP073715:c4025056-4024814 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT200065 NZ_CP097697:356153-356452 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I6CHB9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References