Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3376571..3377191 Replicon chromosome
Accession NZ_CP073715
Organism Salmonella enterica subsp. enterica serovar Bovismorbificans strain 2020LSAL11867

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag KCG42_RS16480 Protein ID WP_001280991.1
Coordinates 3376973..3377191 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag KCG42_RS16475 Protein ID WP_000344807.1
Coordinates 3376571..3376945 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KCG42_RS16465 (3371710) 3371710..3372903 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KCG42_RS16470 (3372926) 3372926..3376075 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
KCG42_RS16475 (3376571) 3376571..3376945 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
KCG42_RS16480 (3376973) 3376973..3377191 + 219 WP_001280991.1 HHA domain-containing protein Toxin
KCG42_RS16485 (3377370) 3377370..3377921 + 552 WP_001278792.1 maltose O-acetyltransferase -
KCG42_RS16490 (3378039) 3378039..3378509 + 471 WP_000136183.1 YlaC family protein -
KCG42_RS16495 (3378565) 3378565..3378705 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
KCG42_RS16500 (3378711) 3378711..3378971 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
KCG42_RS16505 (3379196) 3379196..3380746 + 1551 WP_024792601.1 EAL domain-containing protein -
KCG42_RS16515 (3380977) 3380977..3381366 + 390 WP_000961285.1 MGMT family protein -
KCG42_RS16520 (3381399) 3381399..3381968 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T200064 WP_001280991.1 NZ_CP073715:3376973-3377191 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T200064 NZ_CP097697:329836-330204 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT200064 WP_000344807.1 NZ_CP073715:3376571-3376945 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT200064 NZ_CP097697:329618-329839 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References