Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 837327..837952 Replicon chromosome
Accession NZ_CP073715
Organism Salmonella enterica subsp. enterica serovar Bovismorbificans strain 2020LSAL11867

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KCG42_RS04040 Protein ID WP_000911337.1
Coordinates 837554..837952 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID C0PXM4
Locus tag KCG42_RS04035 Protein ID WP_000557545.1
Coordinates 837327..837554 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KCG42_RS04005 (832423) 832423..833521 + 1099 WP_096059418.1 peptide chain release factor 2 -
KCG42_RS04010 (833531) 833531..835048 + 1518 WP_000003339.1 lysine--tRNA ligase -
KCG42_RS04015 (835124) 835124..835669 - 546 WP_021000753.1 isopentenyl-diphosphate Delta-isomerase -
KCG42_RS04020 (835934) 835934..836692 + 759 WP_000244328.1 amidase activator ActS -
KCG42_RS04030 (836938) 836938..837150 - 213 WP_024133381.1 hypothetical protein -
KCG42_RS04035 (837327) 837327..837554 + 228 WP_000557545.1 toxin-antitoxin system antitoxin VapB Antitoxin
KCG42_RS04040 (837554) 837554..837952 + 399 WP_000911337.1 tRNA(fMet)-specific endonuclease VapC Toxin
KCG42_RS04045 (838758) 838758..839294 + 537 WP_001038500.1 STM3031 family outer membrane protein -
KCG42_RS04050 (839341) 839341..839973 + 633 WP_000835265.1 YfdX family protein -
KCG42_RS04055 (840692) 840692..841276 + 585 WP_021000750.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 836938..847144 10206


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15037.43 Da        Isoelectric Point: 7.7785

>T200053 WP_000911337.1 NZ_CP073715:837554-837952 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T200053 NZ_CP097694:1994604-1994706 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8500.48 Da        Isoelectric Point: 5.0053

>AT200053 WP_000557545.1 NZ_CP073715:837327-837554 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
MHTTLFFSNRTQAVRLPKSISFPDDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT200053 NZ_CP097694:c1994713-1994568 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9MGW6

References