Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 827599..828259 Replicon chromosome
Accession NZ_CP073715
Organism Salmonella enterica subsp. enterica serovar Bovismorbificans strain 2020LSAL11867

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag KCG42_RS03980 Protein ID WP_000244756.1
Coordinates 827846..828259 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag KCG42_RS03975 Protein ID WP_000351186.1
Coordinates 827599..827865 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KCG42_RS03955 (823527) 823527..824960 - 1434 WP_021000757.1 6-phospho-beta-glucosidase BglA -
KCG42_RS03960 (825119) 825119..825430 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
KCG42_RS03965 (825594) 825594..826253 + 660 WP_000250289.1 hemolysin III family protein -
KCG42_RS03970 (826369) 826369..827349 - 981 WP_000874176.1 tRNA-modifying protein YgfZ -
KCG42_RS03975 (827599) 827599..827865 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
KCG42_RS03980 (827846) 827846..828259 + 414 WP_000244756.1 protein YgfX Toxin
KCG42_RS03985 (828312) 828312..828833 - 522 WP_001055885.1 flavodoxin FldB -
KCG42_RS03990 (828946) 828946..829842 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
KCG42_RS03995 (829866) 829866..830579 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KCG42_RS04000 (830585) 830585..832318 + 1734 WP_000813385.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T200052 WP_000244756.1 NZ_CP073715:827846-828259 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T200052 NZ_CP097694:876362-876769 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT200052 WP_000351186.1 NZ_CP073715:827599-827865 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT200052 NZ_CP097694:876115-876381 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References