Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 205104..205864 Replicon chromosome
Accession NZ_CP073715
Organism Salmonella enterica subsp. enterica serovar Bovismorbificans strain 2020LSAL11867

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag KCG42_RS00955 Protein ID WP_000533909.1
Coordinates 205379..205864 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag KCG42_RS00950 Protein ID WP_000965886.1
Coordinates 205104..205391 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KCG42_RS00935 (200727) 200727..202796 + 2070 WP_021000891.1 glycine--tRNA ligase subunit beta -
KCG42_RS22525 (203058) 203058..203459 + 402 Protein_187 IS3 family transposase -
KCG42_RS00945 (203853) 203853..204758 + 906 WP_021000890.1 hypothetical protein -
KCG42_RS00950 (205104) 205104..205391 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
KCG42_RS00955 (205379) 205379..205864 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
KCG42_RS00960 (206235) 206235..206774 - 540 WP_000047148.1 copper-binding periplasmic metallochaperone CueP -
KCG42_RS00965 (206948) 206948..207160 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
KCG42_RS00970 (207448) 207448..207738 - 291 WP_000455790.1 HTH-type transcriptional regulator -
KCG42_RS00975 (208177) 208177..208887 + 711 WP_000190524.1 DUF3053 domain-containing protein -
KCG42_RS00980 (208937) 208937..209911 - 975 WP_021000888.1 glyoxylate/hydroxypyruvate reductase GhrB -
KCG42_RS00985 (210130) 210130..210792 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T200050 WP_000533909.1 NZ_CP073715:205379-205864 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T200050 NZ_CP097694:354959-355306 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT200050 WP_000965886.1 NZ_CP073715:205104-205391 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT200050 NZ_CP097694:355306-355605 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References