Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PumA-relB/upstrm_HI1419-dnstrm_HI1420 |
| Location | 85828..86422 | Replicon | plasmid unnamed3 |
| Accession | NZ_CP073707 | ||
| Organism | Burkholderia cenocepacia strain toggle3 | ||
Toxin (Protein)
| Gene name | PumA | Uniprot ID | - |
| Locus tag | KEH57_RS36825 | Protein ID | WP_175836042.1 |
| Coordinates | 86129..86422 (-) | Length | 98 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A228JAU5 |
| Locus tag | KEH57_RS36820 | Protein ID | WP_027811056.1 |
| Coordinates | 85828..86127 (-) | Length | 100 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KEH57_RS36800 (KEH57_36800) | 80972..81409 | - | 438 | WP_212267561.1 | protein-disulfide reductase DsbD N-terminal domain-containing protein | - |
| KEH57_RS36805 (KEH57_36805) | 81406..83328 | - | 1923 | WP_175836036.1 | type IV secretion system DNA-binding domain-containing protein | - |
| KEH57_RS36810 (KEH57_36810) | 83325..83753 | - | 429 | WP_175836038.1 | hypothetical protein | - |
| KEH57_RS36815 (KEH57_36815) | 85352..85663 | + | 312 | WP_212267560.1 | hypothetical protein | - |
| KEH57_RS36820 (KEH57_36820) | 85828..86127 | - | 300 | WP_027811056.1 | putative addiction module antidote protein | Antitoxin |
| KEH57_RS36825 (KEH57_36825) | 86129..86422 | - | 294 | WP_175836042.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| KEH57_RS36830 (KEH57_36830) | 86521..86685 | - | 165 | WP_175836043.1 | hypothetical protein | - |
| KEH57_RS36835 (KEH57_36835) | 86721..87017 | - | 297 | WP_175836045.1 | hypothetical protein | - |
| KEH57_RS36840 (KEH57_36840) | 87070..87213 | - | 144 | WP_212267558.1 | hypothetical protein | - |
| KEH57_RS36845 (KEH57_36845) | 87270..87491 | - | 222 | WP_175836049.1 | DUF3717 domain-containing protein | - |
| KEH57_RS36850 (KEH57_36850) | 87519..87800 | - | 282 | WP_175836051.1 | hypothetical protein | - |
| KEH57_RS36855 (KEH57_36855) | 87856..88116 | - | 261 | WP_175836053.1 | hypothetical protein | - |
| KEH57_RS37575 | 89132..89320 | - | 189 | WP_249216166.1 | hypothetical protein | - |
| KEH57_RS36860 (KEH57_36860) | 89313..91112 | - | 1800 | WP_249216167.1 | ParB N-terminal domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..134199 | 134199 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 98 a.a. Molecular weight: 10858.43 Da Isoelectric Point: 10.6086
>T200043 WP_175836042.1 NZ_CP073707:c86422-86129 [Burkholderia cenocepacia]
MRIEQTDDFAKWLRGLRDHIARAQIAKRIQRLARGQYGDVKSVGSGVSEMRVHVGPGYRVYFVQRGSTLVVLLCGGDKST
QQRDIERAIALSTQLGD
MRIEQTDDFAKWLRGLRDHIARAQIAKRIQRLARGQYGDVKSVGSGVSEMRVHVGPGYRVYFVQRGSTLVVLLCGGDKST
QQRDIERAIALSTQLGD
Download Length: 294 bp
>T200043 NZ_CP097692:c4832902-4832369 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
Antitoxin
Download Length: 100 a.a. Molecular weight: 10716.01 Da Isoelectric Point: 4.6364
>AT200043 WP_027811056.1 NZ_CP073707:c86127-85828 [Burkholderia cenocepacia]
MGIKTTPFDAAEYLDTPEAQAEYLRISFETGDSADIQEAIGTVARARGMTQIARDAGVGRESLYKALDEHGNPEFATILR
VVRALGLTLTVTTPVHEHA
MGIKTTPFDAAEYLDTPEAQAEYLRISFETGDSADIQEAIGTVARARGMTQIARDAGVGRESLYKALDEHGNPEFATILR
VVRALGLTLTVTTPVHEHA
Download Length: 300 bp
>AT200043 NZ_CP097692:c4833179-4832913 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|