200038

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1770493..1771132 Replicon chromosome
Accession NZ_CP073704
Organism Burkholderia cenocepacia strain toggle3

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KEH57_RS30010 Protein ID WP_006481544.1
Coordinates 1770493..1770909 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KEH57_RS30015 Protein ID WP_059720844.1
Coordinates 1770896..1771132 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KEH57_RS29985 (KEH57_29985) 1765591..1766691 - 1101 WP_034202287.1 nitronate monooxygenase -
KEH57_RS29990 (KEH57_29990) 1766688..1767617 - 930 WP_077021150.1 enoyl-CoA hydratase -
KEH57_RS29995 (KEH57_29995) 1767626..1768423 - 798 WP_212267056.1 ketoacid CoA transferase -
KEH57_RS30000 (KEH57_30000) 1768434..1769327 - 894 WP_048988182.1 CoA-transferase -
KEH57_RS30005 (KEH57_30005) 1769337..1770233 - 897 WP_058903174.1 VOC family protein -
KEH57_RS30010 (KEH57_30010) 1770493..1770909 - 417 WP_006481544.1 type II toxin-antitoxin system VapC family toxin Toxin
KEH57_RS30015 (KEH57_30015) 1770896..1771132 - 237 WP_059720844.1 hypothetical protein Antitoxin
KEH57_RS30020 (KEH57_30020) 1771625..1772851 + 1227 WP_034202283.1 acyltransferase -
KEH57_RS30025 (KEH57_30025) 1772862..1773539 - 678 WP_077176171.1 hypothetical protein -
KEH57_RS30030 (KEH57_30030) 1774188..1774961 - 774 WP_212267054.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15402.64 Da        Isoelectric Point: 6.8818

>T200038 WP_006481544.1 NZ_CP073704:c1770909-1770493 [Burkholderia cenocepacia]
VFLIDTNVISEIRKGKRTNRGVRAFFRQAEADASPLYLSVVTVAELRRGVDLIRHRGDHSQASALEAWLTMILSGYAPNI
LPVDVETGQMWGHLRVPDPTHELDKLIAATALINDLTVVTRNVDDFARTGVRLLNPFE

Download         Length: 417 bp

>T200038 NZ_CP097692:742798-743283 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8726.85 Da        Isoelectric Point: 5.0914

>AT200038 WP_059720844.1 NZ_CP073704:c1771132-1770896 [Burkholderia cenocepacia]
MANLLVRNVDDTLVQCLREQAAANGRSAEAEHRAILAEALGRPKRRTFAQVLMSMPEVGEDADFQRVQDSGEVRRVFD

Download         Length: 237 bp

>AT200038 NZ_CP097692:742508-742801 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References