200037

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1249933..1250579 Replicon chromosome
Accession NZ_CP073704
Organism Burkholderia cenocepacia strain toggle3

Toxin (Protein)


Gene name vapC Uniprot ID A0A1V2W4R9
Locus tag KEH57_RS27755 Protein ID WP_062885461.1
Coordinates 1250172..1250579 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B4EGU8
Locus tag KEH57_RS27750 Protein ID WP_006491146.1
Coordinates 1249933..1250175 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KEH57_RS27735 (KEH57_27735) 1245928..1247334 + 1407 WP_034202505.1 aspartate ammonia-lyase -
KEH57_RS27740 (KEH57_27740) 1247412..1248917 + 1506 WP_212273162.1 amino acid permease -
KEH57_RS27745 (KEH57_27745) 1248991..1249674 - 684 WP_080331177.1 phospholipase -
KEH57_RS27750 (KEH57_27750) 1249933..1250175 + 243 WP_006491146.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
KEH57_RS27755 (KEH57_27755) 1250172..1250579 + 408 WP_062885461.1 type II toxin-antitoxin system VapC family toxin Toxin
KEH57_RS27760 (KEH57_27760) 1250980..1253355 + 2376 WP_034202502.1 MCP four helix bundle domain-containing protein -
KEH57_RS37680 (KEH57_27765) 1253378..1254106 + 729 WP_058903588.1 methyl-accepting chemotaxis protein -
KEH57_RS27770 (KEH57_27770) 1254103..1254684 + 582 WP_058902967.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

SpoVT-AbrB domain

(7-49)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14936.05 Da        Isoelectric Point: 6.2179

>T200037 WP_062885461.1 NZ_CP073704:1250172-1250579 [Burkholderia cenocepacia]
MKFLLDTNAVIAILKGEPAILARLHAWHPADFGIPAIVAHELYYGAYKSQRAAANVARVDALQFEVVSFDTEDAQHAGEI
RAHLIAAGTPIGPYDALIAGQARARQLVLVTHNVREFERVPRLQFEDWLAEPRAD

Download         Length: 408 bp

>T200037 NZ_CP097692:355284-355631 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.02 Da        Isoelectric Point: 5.0197

>AT200037 WP_006491146.1 NZ_CP073704:1249933-1250175 [Burkholderia cenocepacia]
MDTAKLFKHGGSQAVRLPKDFRFDTAEVRIRRHGAAVILEPMPQDWAWLAPLIGPVDADFEAAATTQPSAQERSGLDVFE

Download         Length: 243 bp

>AT200037 NZ_CP097692:355631-355930 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1V2W4R9

Antitoxin

Source ID Structure
AlphaFold DB B4EGU8

References