200036

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 894319..894939 Replicon chromosome
Accession NZ_CP073704
Organism Burkholderia cenocepacia strain toggle3

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KEH57_RS26220 Protein ID WP_109342363.1
Coordinates 894622..894939 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KEH57_RS26215 Protein ID WP_006490972.1
Coordinates 894319..894618 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KEH57_RS26190 (KEH57_26190) 889539..890810 + 1272 WP_212266229.1 anthranilate 1,2-dioxygenase large subunit AndAc -
KEH57_RS26195 (KEH57_26195) 890826..891302 + 477 WP_006490977.1 anthranilate 1,2-dioxygenase small subunit AndAd -
KEH57_RS26200 (KEH57_26200) 891338..891664 + 327 WP_006496019.1 anthranilate 1,2-dioxygenase ferredoxin subunit AndAb -
KEH57_RS26205 (KEH57_26205) 891654..892874 + 1221 WP_212266227.1 anthranilate 1,2-dioxygenase system ferredoxin--NAD(+) reductase -
KEH57_RS26210 (KEH57_26210) 892984..894270 + 1287 WP_212266225.1 DUF445 domain-containing protein -
KEH57_RS26215 (KEH57_26215) 894319..894618 - 300 WP_006490972.1 putative addiction module antidote protein Antitoxin
KEH57_RS26220 (KEH57_26220) 894622..894939 - 318 WP_109342363.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KEH57_RS26225 (KEH57_26225) 895328..896968 + 1641 WP_006490980.1 acetolactate synthase large subunit -
KEH57_RS26230 (KEH57_26230) 896997..898430 + 1434 WP_006490987.1 aldehyde dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(9-100)

Antitoxin

Uncharacterized protein HI1420

(4-96)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11826.55 Da        Isoelectric Point: 7.2769

>T200036 WP_109342363.1 NZ_CP073704:c894939-894622 [Burkholderia cenocepacia]
MPYSPPAFSIRTTDVFDAWFAGLPDRLAKRRIQARIDRLSMGNPGDWKSAGSPVVEMRIDHGPGYRVYDVRRETIWVILL
CGGDQSTQLADIRAAHAMLAHLDME

Download         Length: 318 bp

>T200036 NZ_CP097692:329313-329681 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10608.04 Da        Isoelectric Point: 6.4771

>AT200036 WP_006490972.1 NZ_CP073704:c894618-894319 [Burkholderia cenocepacia]
MDKIKTRPWDSAEHLKTEDDMADYFDACLQEAGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAAA

Download         Length: 300 bp

>AT200036 NZ_CP097692:329095-329316 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References