200035

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 584839..585503 Replicon chromosome
Accession NZ_CP073703
Organism Burkholderia cenocepacia strain toggle3

Toxin (Protein)


Gene name relE Uniprot ID A0A1V2W836
Locus tag KEH57_RS20350 Protein ID WP_059722920.1
Coordinates 585207..585503 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KEH57_RS20345 Protein ID WP_059722922.1
Coordinates 584839..585204 (-) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KEH57_RS20330 (KEH57_20330) 580138..582777 + 2640 WP_212203576.1 cytochrome c oxidase subunit I -
KEH57_RS20335 (KEH57_20335) 582774..583175 + 402 WP_048987230.1 hypothetical protein -
KEH57_RS20340 (KEH57_20340) 583166..584748 + 1583 Protein_516 cytochrome c -
KEH57_RS20345 (KEH57_20345) 584839..585204 - 366 WP_059722922.1 putative addiction module antidote protein Antitoxin
KEH57_RS20350 (KEH57_20350) 585207..585503 - 297 WP_059722920.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KEH57_RS20355 (KEH57_20355) 585656..587116 - 1461 WP_059722918.1 TolC family protein -
KEH57_RS20360 (KEH57_20360) 587194..587811 + 618 WP_059722917.1 TetR/AcrR family transcriptional regulator -
KEH57_RS20365 (KEH57_20365) 587894..589018 + 1125 WP_059722915.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Uncharacterized protein HI1420

(5-92)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10775.58 Da        Isoelectric Point: 10.3618

>T200035 WP_059722920.1 NZ_CP073703:c585503-585207 [Burkholderia cenocepacia]
MFKVLTTPQFDKWLGGLRDPVGSAAISLRIERAKLGNLGQWRAIGDGVNEMKIDVGPGYRAYFVRRGKIIVVVLCGGDKS
TQKKDIKTAKQIAAELED

Download         Length: 297 bp

>T200035 NZ_CP097691:72434-72583 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 12903.57 Da        Isoelectric Point: 8.5514

>AT200035 WP_059722922.1 NZ_CP073703:c585204-584839 [Burkholderia cenocepacia]
MKISELAEFDGSKYLKDEEAIRHYLAQAFEDGDPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVAALGLHLTVAPTTQNAEAGRGPEPTSRTRSHARAAAHG

Download         Length: 366 bp

>AT200035 NZ_CP097691:c72389-72330 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1V2W836

Antitoxin

Source ID Structure

References