Detailed information of TA system TA200034

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-vagC/VapC-VagC
• Location: 3670174..3670811
• Replicon: chromosome
• Accession: NZ_CP073702
• Organism: Burkholderia cenocepacia strain toggle3

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: KEH57_RS17115
• Protein ID: WP_058902008.1
• Coordinates: 3670174..3670575 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: A0A364GPY9
• Locus tag: KEH57_RS17120
• Protein ID: WP_034201144.1
• Coordinates: 3670575..3670811 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KEH57_RS17105 (KEH57_17105)	3667558..3668688	+	1131	WP_230391081.1	alginate lyase family protein	-
KEH57_RS17110 (KEH57_17110)	3668719..3670107	+	1389	WP_006485681.1	L-serine ammonia-lyase	-
KEH57_RS17115 (KEH57_17115)	3670174..3670575	-	402	WP_058902008.1	type II toxin-antitoxin system VapC family toxin	Toxin
KEH57_RS17120 (KEH57_17120)	3670575..3670811	-	237	WP_034201144.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
KEH57_RS17125 (KEH57_17125)	3670929..3671158	-	230	Protein_3364	type II toxin-antitoxin system RelE/ParE family toxin	-
KEH57_RS17130 (KEH57_17130)	3671527..3673230	+	1704	WP_059721116.1	thiamine pyrophosphate-binding protein	-
KEH57_RS17135 (KEH57_17135)	3673227..3674324	+	1098	WP_062884188.1	hypothetical protein	-
KEH57_RS17140 (KEH57_17140)	3674419..3675435	-	1017	WP_006493582.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-120)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 15043.22 Da
• Isoelectric Point: 5.6634

>T200034 WP_058902008.1 NZ_CP073702:c3670575-3670174 [Burkholderia cenocepacia]
MPRFMLDTNMCIYLMKNQPEQVARRFAQCYTGDVVMSAITYAELEYGLTACANPARERRHLAALIEDIPVAPFDAAAAQA
YGPVREATRERKKDHLDKLIAAHAVSLDVVLVTNNERDFVSYPGLRLENWLND

Nucleotide

• Length: 402 bp

>T200034 NZ_CP097690:c183815-183333 [Klebsiella pneumoniae]
ATGGGAATGAGAGCGCCTGAATCCCTGACGGCTGAACATAACATCGCTGAGTTCTGCTGCCAGGAGCCTGCCCTTAATGA
GTGGTTAAAGAAGAAGGCTCTCAGAAACCACAGTACCGGCATTTCCCGTGTCTATGTCGTCTGCGCAGAAAACACTAACC
GGGTCATCGGTTATTATTGTTTATCTTCGGGTAGCGTCCACCGTAACACAGTGCCTGGGGCCTATAGACGCAACGCGCCT
GATGTCATTCCAGTCATTGTTTTGGGACGGCTTGCCATCGACCAGGCCTGGGCCGGGAATGGGCTTGGTGCCGCACTTCT
TAAGGATGCTATATACCGTACGCAAAACATAGCCTTTCAGGTCGGGGTGAGAGCACTGGCCGTGCATGCGCTGAATGAAG
AAGTTAAATGTTTTTACACCCGTTTTGGCTTTGAGCCTTCCATAGTCAACACGCTGACATTGTTATTCCCGATAAAAGTC
TGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8982.15 Da
• Isoelectric Point: 6.4701

>AT200034 WP_034201144.1 NZ_CP073702:c3670811-3670575 [Burkholderia cenocepacia]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERVGDEIRIRPMRRPLTQVLAKFAKFGPDFMADGRGDHEQAEREGL

Nucleotide

• Length: 237 bp

>AT200034 NZ_CP097690:c184084-183806 [Klebsiella pneumoniae]
ATGAAACCAGACGTTCGTGAAGCTCCGATTAATATCCGGGCCAAAACATCACAGCGTGACCTGATCGACATGGCCGCAAG
CCTGGTCTCAAAATCACGGACTGATTTTATGCTTGAGGTTGCCTGCAGGGAGGCACAGGACATTCTGCTTGATCAACGCC
TGTTCCTCCTCAATGACAATCAGTTTGAGGCGTTTATTGAAGAGCTTGACGCCCCAATAACGCCGGAGCGCCAGGCGCGA
ATCGATAACCTGATGAACCGCAAATCACCATGGGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A364GPY9