Detailed information of TA system TA200031

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 1219423..1219979
• Replicon: chromosome
• Accession: NZ_CP073702
• Organism: Burkholderia cenocepacia strain toggle3

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: KEH57_RS05655
• Protein ID: WP_229202334.1
• Coordinates: 1219728..1219979 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: M4UBZ0
• Locus tag: KEH57_RS05650
• Protein ID: WP_004541313.1
• Coordinates: 1219423..1219701 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KEH57_RS05630 (KEH57_05630)	1214894..1216165	+	1272	WP_212272787.1	hypothetical protein	-
KEH57_RS05635 (KEH57_05635)	1216299..1216556	-	258	WP_041195370.1	hypothetical protein	-
KEH57_RS05640 (KEH57_05640)	1217046..1217315	+	270	WP_201455650.1	plasmid mobilization protein MobA	-
KEH57_RS05645 (KEH57_05645)	1217318..1219342	+	2025	WP_249216109.1	relaxase/mobilization nuclease domain-containing protein	-
KEH57_RS05650 (KEH57_05650)	1219423..1219701	+	279	WP_004541313.1	CopG family ribbon-helix-helix protein	Antitoxin
KEH57_RS05655 (KEH57_05655)	1219728..1219979	+	252	WP_229202334.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KEH57_RS05660 (KEH57_05660)	1219982..1220296	+	315	WP_023872355.1	hypothetical protein	-
KEH57_RS37610	1220289..1220423	+	135	WP_011051575.1	hypothetical protein	-
KEH57_RS05665 (KEH57_05665)	1220492..1220740	+	249	WP_059478629.1	hypothetical protein	-
KEH57_RS05670 (KEH57_05670)	1220845..1221504	+	660	WP_212267859.1	hypothetical protein	-
KEH57_RS05675 (KEH57_05675)	1221546..1223747	-	2202	WP_212272788.1	AAA family ATPase	-
KEH57_RS05680 (KEH57_05680)	1223976..1224497	-	522	WP_212267855.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1188721..1222856	34135

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-81)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9594.91 Da
• Isoelectric Point: 9.9718

>T200031 WP_229202334.1 NZ_CP073702:1219728-1219979 [Burkholderia cenocepacia]
MQRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLPEQYREWLIDFGDSGYVARYRLDGDTVTILAVRHQKE
AGY

Nucleotide

• Length: 252 bp

>T200031 NZ_CP097690:1352-1636 [Klebsiella pneumoniae]
ATGACTTATAAGCTGGCCTTTAATGAATCAGCTCTGAAAGAATGGAAAAAATTGGGCCATACCATTCGGGAACAATTCAA
AAAGAAGCTCGCTGAGCGCCTGTTGAACCCACGGGTGCCCGCATCGCAACTACATGGACGCAAAGACCAATACAAAATAA
AGCTCCGTGGCGCAGGCTACCGACTGGTTTACAGTGTCAACGATGATGTTGTGACGGTCACCGTAATTGGCGTCGGTAAA
CGTGAGAATGATGATATTTACAATTTAACCAAACACAGAAATTAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10810.11 Da
• Isoelectric Point: 4.9736

>AT200031 WP_004541313.1 NZ_CP073702:1219423-1219701 [Burkholderia cenocepacia]
MVTATSIKLDDELKGRVQHLAEARRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT200031 NZ_CP097690:1114-1362 [Klebsiella pneumoniae]
ATGGCATTTCAGGTACTAACCACTACTGCAGCAAGCATCACAGAGCTTAAACGTGATCCTATGGGCACTTTCAATGCAGG
AGAAGGTGCCCCTGTAGCCATACTGAATCGCAACGAACCCGCTTTTTACTGTGTACCGCCTGCTCTGTATGCTCAACTGA
TGGAGCTTCTTGAAGATCAGGAGCTGGGTCGTATTGCTGATGAGCGAATTGGTGAGGCGGTAATCGAGGTCAGTCTAGAT
GACTTATAA

Structures

Antitoxin

• AlphaFold DB: M4UBZ0