Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-StbC |
Location | 4513556..4514235 | Replicon | chromosome |
Accession | NZ_CP073677 | ||
Organism | Cupriavidus sp. KK10 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | - |
Locus tag | KB879_RS21040 | Protein ID | WP_211979716.1 |
Coordinates | 4513807..4514235 (+) | Length | 143 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | - |
Locus tag | KB879_RS21035 | Protein ID | WP_041228808.1 |
Coordinates | 4513556..4513810 (+) | Length | 85 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KB879_RS21010 (KB879_21010) | 4509210..4509671 | - | 462 | WP_013952348.1 | MaoC family dehydratase N-terminal domain-containing protein | - |
KB879_RS21015 (KB879_21015) | 4509668..4510891 | - | 1224 | WP_013952349.1 | CoA transferase | - |
KB879_RS21020 (KB879_21020) | 4510998..4511888 | + | 891 | WP_153955479.1 | LysR family transcriptional regulator | - |
KB879_RS21025 (KB879_21025) | 4511913..4513109 | - | 1197 | WP_153955480.1 | helix-turn-helix transcriptional regulator | - |
KB879_RS21030 (KB879_21030) | 4513177..4513557 | - | 381 | WP_211979715.1 | hypothetical protein | - |
KB879_RS21035 (KB879_21035) | 4513556..4513810 | + | 255 | WP_041228808.1 | plasmid stabilization protein | Antitoxin |
KB879_RS21040 (KB879_21040) | 4513807..4514235 | + | 429 | WP_211979716.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
KB879_RS21045 (KB879_21045) | 4514263..4516632 | - | 2370 | WP_211979717.1 | mechanosensitive ion channel family protein | - |
KB879_RS21050 (KB879_21050) | 4516897..4517679 | + | 783 | WP_013952356.1 | SDR family NAD(P)-dependent oxidoreductase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 143 a.a. Molecular weight: 14961.24 Da Isoelectric Point: 5.1006
>T200025 WP_211979716.1 NZ_CP073677:4513807-4514235 [Cupriavidus sp. KK10]
MIVLDTNVISEAMKPEPADSVRCWLNDQAAETLYLSSVTLAELLFGIGALPAGRRRAMLAAALDGLVTLFEGRILPFDTN
AARHYAELATAARSRGRGLPTPDGHIAAIAAANGMIVATRDVSPFEAAGLQVLNPWLAPPPS
MIVLDTNVISEAMKPEPADSVRCWLNDQAAETLYLSSVTLAELLFGIGALPAGRRRAMLAAALDGLVTLFEGRILPFDTN
AARHYAELATAARSRGRGLPTPDGHIAAIAAANGMIVATRDVSPFEAAGLQVLNPWLAPPPS
Download Length: 429 bp
>T200025 NZ_CP097688:4275487-4275705 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA
Antitoxin
Download Length: 85 a.a. Molecular weight: 9175.52 Da Isoelectric Point: 7.0159
>AT200025 WP_041228808.1 NZ_CP073677:4513556-4513810 [Cupriavidus sp. KK10]
MPILTVRNVPDDVHRALRVRAAQNGRSTEAEVREILASAVMPQKRVRLGDALAMLGREIGLSNADVEAIEQGKDKAAAEP
VRFE
MPILTVRNVPDDVHRALRVRAAQNGRSTEAEVREILASAVMPQKRVRLGDALAMLGREIGLSNADVEAIEQGKDKAAAEP
VRFE
Download Length: 255 bp
>AT200025 NZ_CP097688:4275086-4275460 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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