Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 4513556..4514235 Replicon chromosome
Accession NZ_CP073677
Organism Cupriavidus sp. KK10

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KB879_RS21040 Protein ID WP_211979716.1
Coordinates 4513807..4514235 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KB879_RS21035 Protein ID WP_041228808.1
Coordinates 4513556..4513810 (+) Length 85 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KB879_RS21010 (KB879_21010) 4509210..4509671 - 462 WP_013952348.1 MaoC family dehydratase N-terminal domain-containing protein -
KB879_RS21015 (KB879_21015) 4509668..4510891 - 1224 WP_013952349.1 CoA transferase -
KB879_RS21020 (KB879_21020) 4510998..4511888 + 891 WP_153955479.1 LysR family transcriptional regulator -
KB879_RS21025 (KB879_21025) 4511913..4513109 - 1197 WP_153955480.1 helix-turn-helix transcriptional regulator -
KB879_RS21030 (KB879_21030) 4513177..4513557 - 381 WP_211979715.1 hypothetical protein -
KB879_RS21035 (KB879_21035) 4513556..4513810 + 255 WP_041228808.1 plasmid stabilization protein Antitoxin
KB879_RS21040 (KB879_21040) 4513807..4514235 + 429 WP_211979716.1 type II toxin-antitoxin system VapC family toxin Toxin
KB879_RS21045 (KB879_21045) 4514263..4516632 - 2370 WP_211979717.1 mechanosensitive ion channel family protein -
KB879_RS21050 (KB879_21050) 4516897..4517679 + 783 WP_013952356.1 SDR family NAD(P)-dependent oxidoreductase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-121)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 143 a.a.        Molecular weight: 14961.24 Da        Isoelectric Point: 5.1006

>T200025 WP_211979716.1 NZ_CP073677:4513807-4514235 [Cupriavidus sp. KK10]
MIVLDTNVISEAMKPEPADSVRCWLNDQAAETLYLSSVTLAELLFGIGALPAGRRRAMLAAALDGLVTLFEGRILPFDTN
AARHYAELATAARSRGRGLPTPDGHIAAIAAANGMIVATRDVSPFEAAGLQVLNPWLAPPPS

Download         Length: 429 bp

>T200025 NZ_CP097688:4275487-4275705 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9175.52 Da        Isoelectric Point: 7.0159

>AT200025 WP_041228808.1 NZ_CP073677:4513556-4513810 [Cupriavidus sp. KK10]
MPILTVRNVPDDVHRALRVRAAQNGRSTEAEVREILASAVMPQKRVRLGDALAMLGREIGLSNADVEAIEQGKDKAAAEP
VRFE

Download         Length: 255 bp

>AT200025 NZ_CP097688:4275086-4275460 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References