200024

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3397046..3397689 Replicon chromosome
Accession NZ_CP073677
Organism Cupriavidus sp. KK10

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KB879_RS15960 Protein ID WP_211979398.1
Coordinates 3397046..3397447 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID F8GSK5
Locus tag KB879_RS15965 Protein ID WP_013953739.1
Coordinates 3397447..3397689 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KB879_RS15945 (KB879_15945) 3392322..3392807 + 486 WP_013953735.1 DM13 domain-containing protein -
KB879_RS15950 (KB879_15950) 3392981..3394051 - 1071 WP_211979396.1 porin -
KB879_RS15955 (KB879_15955) 3394362..3396989 + 2628 WP_211979397.1 transglycosylase domain-containing protein -
KB879_RS15960 (KB879_15960) 3397046..3397447 - 402 WP_211979398.1 type II toxin-antitoxin system VapC family toxin Toxin
KB879_RS15965 (KB879_15965) 3397447..3397689 - 243 WP_013953739.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
KB879_RS15970 (KB879_15970) 3397823..3399145 - 1323 WP_211979399.1 DUF1501 domain-containing protein -
KB879_RS15975 (KB879_15975) 3399159..3400748 - 1590 WP_211979400.1 DUF1800 domain-containing protein -
KB879_RS15980 (KB879_15980) 3400948..3401871 + 924 WP_211979401.1 DMT family transporter -
KB879_RS15985 (KB879_15985) 3401855..3402619 + 765 WP_211979402.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin

SpoVT-AbrB domain

(13-48)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13886.02 Da        Isoelectric Point: 6.4437

>T200024 WP_211979398.1 NZ_CP073677:c3397447-3397046 [Cupriavidus sp. KK10]
MSLFLLDTNIISDAIRNTRGPCAARIAALEPDSLCTSIIVAAELRFGAAKKGSPALSQRVGQALAGLRVLPLGGDADACY
GELRAGLERSGRVIGANDMLIAAHALSLGAVLVTDNIGEFSHVDGLRCENWLK

Download         Length: 402 bp

>T200024 NZ_CP097688:c2824984-2823662 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCTGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9281.58 Da        Isoelectric Point: 4.4791

>AT200024 WP_013953739.1 NZ_CP073677:c3397689-3397447 [Cupriavidus sp. KK10]
MTTTDEIRHVRLFRNGRNQAIRIPREFELPGEEAILRREGNHLIIEPVAAMPLRSLLAQWEPIDVDWPTIDNLPAEDVDL

Download         Length: 243 bp

>AT200024 NZ_CP097688:c2825250-2824984 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB F8GSK5

References