Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3222147..3222805 Replicon chromosome
Accession NZ_CP073677
Organism Cupriavidus sp. KK10

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KB879_RS15185 Protein ID WP_211981994.1
Coordinates 3222147..3222557 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KB879_RS15190 Protein ID WP_041228698.1
Coordinates 3222554..3222805 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KB879_RS15165 (KB879_15165) 3217765..3218739 - 975 WP_211981988.1 LysR family transcriptional regulator -
KB879_RS15170 (KB879_15170) 3218829..3220058 + 1230 WP_013953590.1 CoA transferase -
KB879_RS15175 (KB879_15175) 3220055..3221065 + 1011 WP_211981990.1 NADPH:quinone oxidoreductase family protein -
KB879_RS15180 (KB879_15180) 3221119..3222066 + 948 WP_249221339.1 tripartite tricarboxylate transporter substrate binding protein -
KB879_RS15185 (KB879_15185) 3222147..3222557 - 411 WP_211981994.1 type II toxin-antitoxin system VapC family toxin Toxin
KB879_RS15190 (KB879_15190) 3222554..3222805 - 252 WP_041228698.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
KB879_RS15195 (KB879_15195) 3223164..3224339 + 1176 WP_013953595.1 branched-chain amino acid ABC transporter substrate-binding protein -
KB879_RS15200 (KB879_15200) 3224421..3225350 + 930 WP_013953596.1 branched-chain amino acid ABC transporter permease -
KB879_RS15205 (KB879_15205) 3225337..3226548 + 1212 WP_249221313.1 branched-chain amino acid ABC transporter permease -
KB879_RS15210 (KB879_15210) 3226545..3227327 + 783 WP_013953598.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(8-55)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14500.92 Da        Isoelectric Point: 7.2774

>T200023 WP_211981994.1 NZ_CP073677:c3222557-3222147 [Cupriavidus sp. KK10]
MTRYMLDTNIVSHLLRAHPAVVARVTAAPMAALCLSAITGAELMYGLAKRPGAARLARAVDELLRRVEVLPWTPSVMVGY
GETRAALESQGQPMGALDLLIAAHALETGAVLVTNDQAFRRVPGLVVEDWSVPTGN

Download         Length: 411 bp

>T200023 NZ_CP097688:2107653-2107755 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9164.27 Da        Isoelectric Point: 6.3139

>AT200023 WP_041228698.1 NZ_CP073677:c3222805-3222554 [Cupriavidus sp. KK10]
VSTTAKIFTTGRSQAVRLPQEFRFAEREVYIRRDPSTGDVILSRRPESWDGFLAAIKDSAVPADFLAGRAQGEQARDPLA
GLE

Download         Length: 252 bp

>AT200023 NZ_CP097688:c2107762-2107617 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References