Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 394048..394689 Replicon chromosome
Accession NZ_CP073676
Organism Burkholderia cenocepacia strain toggle4

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KEH58_RS23690 Protein ID WP_077021707.1
Coordinates 394351..394689 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KEH58_RS23685 Protein ID WP_006490972.1
Coordinates 394048..394347 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KEH58_RS23660 (KEH58_23660) 389281..390552 + 1272 WP_058902844.1 anthranilate 1,2-dioxygenase large subunit AndAc -
KEH58_RS23665 (KEH58_23665) 390568..391044 + 477 WP_006490977.1 anthranilate 1,2-dioxygenase small subunit AndAd -
KEH58_RS23670 (KEH58_23670) 391080..391406 + 327 WP_006496019.1 anthranilate 1,2-dioxygenase ferredoxin subunit AndAb -
KEH58_RS23675 (KEH58_23675) 391396..392616 + 1221 WP_058902845.1 anthranilate 1,2-dioxygenase system ferredoxin--NAD(+) reductase -
KEH58_RS23680 (KEH58_23680) 392713..393999 + 1287 WP_006490986.1 DUF445 domain-containing protein -
KEH58_RS23685 (KEH58_23685) 394048..394347 - 300 WP_006490972.1 putative addiction module antidote protein Antitoxin
KEH58_RS23690 (KEH58_23690) 394351..394689 - 339 WP_077021707.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KEH58_RS23695 (KEH58_23695) 395057..396697 + 1641 WP_006490980.1 acetolactate synthase large subunit -
KEH58_RS23700 (KEH58_23700) 396726..398159 + 1434 WP_006490987.1 aldehyde dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(16-107)

Antitoxin

Uncharacterized protein HI1420

(4-96)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12516.35 Da        Isoelectric Point: 7.2429

>T200014 WP_077021707.1 NZ_CP073676:c394689-394351 [Burkholderia cenocepacia]
MVDTLQCMPYSPPAFSVRTTDVFDAWFAGLPDRLAKRRIQARIDRLSMGNPGDWKSAGSPVVEMRIDHGPGYRVYDVRRG
TIWVILLCGGDQSAQQADIRAAHAMLAHLDME

Download         Length: 339 bp

>T200014 NZ_CP097683:c5401457-5401074 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10608.04 Da        Isoelectric Point: 6.4771

>AT200014 WP_006490972.1 NZ_CP073676:c394347-394048 [Burkholderia cenocepacia]
MDKIKTRPWDSAEHLKTEDDMADYFDACLQEAGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAAA

Download         Length: 300 bp

>AT200014 NZ_CP097683:c5401699-5401457 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References