Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 1962717..1963251 Replicon chromosome
Accession NZ_CP073674
Organism Burkholderia cenocepacia strain toggle4

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag KEH58_RS09350 Protein ID WP_021033200.1
Coordinates 1962952..1963251 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag KEH58_RS09345 Protein ID WP_021033199.1
Coordinates 1962717..1962962 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KEH58_RS09330 (KEH58_09330) 1959426..1960265 + 840 WP_034201792.1 N(5)-hydroxyornithine transformylase PvdF -
KEH58_RS09335 (KEH58_09335) 1960265..1961281 + 1017 WP_034201946.1 GNAT family N-acetyltransferase -
KEH58_RS09340 (KEH58_09340) 1961439..1962602 + 1164 WP_059723573.1 M20 aminoacylase family protein -
KEH58_RS09345 (KEH58_09345) 1962717..1962962 + 246 WP_021033199.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
KEH58_RS09350 (KEH58_09350) 1962952..1963251 + 300 WP_021033200.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KEH58_RS09355 (KEH58_09355) 1963342..1964646 - 1305 WP_125333102.1 cobyrinate a,c-diamide synthase -
KEH58_RS09360 (KEH58_09360) 1964649..1965251 - 603 WP_006476035.1 cob(I)yrinic acid a,c-diamide adenosyltransferase -
KEH58_RS09365 (KEH58_09365) 1965287..1965664 - 378 WP_006496449.1 cobalamin biosynthesis protein -
KEH58_RS09370 (KEH58_09370) 1965661..1966410 - 750 WP_212136265.1 uroporphyrinogen-III C-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-94)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11720.37 Da        Isoelectric Point: 6.9677

>T200013 WP_021033200.1 NZ_CP073674:1962952-1963251 [Burkholderia cenocepacia]
MAVKGRQLRLTPLAECDLEDIWRYTAEHWSPEQAEHYYRDLIGTMEALARGKKAGRICVVRDGYFRYPAGSHVVFYRETD
ETIDVIRVLHQRMDIERHL

Download         Length: 300 bp

>T200013 NZ_CP097683:c5077947-5077030 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8708.68 Da        Isoelectric Point: 7.3196

>AT200013 WP_021033199.1 NZ_CP073674:1962717-1962962 [Burkholderia cenocepacia]
MSRNTSVSLGDHFAEFVDAQVRSGRYGSASDVVRAGLRLLESHETQMRALQEALKAGEGSGTPKPFDSEAFLARMRATHG
G

Download         Length: 246 bp

>AT200013 NZ_CP097683:c5078711-5077953 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGTCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References