Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 1243136..1244178 | Replicon | chromosome |
| Accession | NZ_CP073674 | ||
| Organism | Burkholderia cenocepacia strain toggle4 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | KEH58_RS06005 | Protein ID | WP_212136808.1 |
| Coordinates | 1243603..1244178 (+) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | I3TV68 |
| Locus tag | KEH58_RS06000 | Protein ID | WP_003050245.1 |
| Coordinates | 1243136..1243606 (+) | Length | 157 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KEH58_RS05965 (KEH58_05965) | 1238527..1239945 | - | 1419 | WP_020924934.1 | TIGR03752 family integrating conjugative element protein | - |
| KEH58_RS05970 (KEH58_05970) | 1239935..1240846 | - | 912 | WP_003105643.1 | TIGR03749 family integrating conjugative element protein | - |
| KEH58_RS05975 (KEH58_05975) | 1240843..1241535 | - | 693 | WP_003105641.1 | TIGR03746 family integrating conjugative element protein | - |
| KEH58_RS05980 (KEH58_05980) | 1241532..1241930 | - | 399 | WP_003105639.1 | TIGR03750 family conjugal transfer protein | - |
| KEH58_RS05985 (KEH58_05985) | 1241943..1242302 | - | 360 | WP_003090173.1 | TIGR03745 family integrating conjugative element membrane protein | - |
| KEH58_RS05990 (KEH58_05990) | 1242319..1242552 | - | 234 | WP_003050225.1 | TIGR03758 family integrating conjugative element protein | - |
| KEH58_RS05995 (KEH58_05995) | 1242549..1242932 | - | 384 | WP_003120001.1 | RAQPRD family integrative conjugative element protein | - |
| KEH58_RS06000 (KEH58_06000) | 1243136..1243606 | + | 471 | WP_003050245.1 | helix-turn-helix domain-containing protein | Antitoxin |
| KEH58_RS06005 (KEH58_06005) | 1243603..1244178 | + | 576 | WP_212136808.1 | PIN domain-containing protein | Toxin |
| KEH58_RS06010 (KEH58_06010) | 1244196..1245110 | + | 915 | WP_003105629.1 | AAA family ATPase | - |
| KEH58_RS06015 (KEH58_06015) | 1245107..1245577 | + | 471 | WP_003105626.1 | type III CBASS phage resistance system CD-NTase-associated protein Cap8 | - |
| KEH58_RS06020 (KEH58_06020) | 1245574..1246074 | + | 501 | WP_003090159.1 | type III CBASS phage resistance system CD-NTase-associated protein Cap7 | - |
| KEH58_RS06025 (KEH58_06025) | 1246074..1246976 | + | 903 | WP_003105624.1 | CBASS oligonucleotide cyclase | - |
| KEH58_RS06030 (KEH58_06030) | 1247015..1247740 | + | 726 | WP_003050273.1 | CBASS effector endonuclease NucC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | blaOXA-4 / aadA5 / floR / tet(G) / sul1 / aac(6')-IIa | - | 1156395..1261536 | 105141 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 21545.66 Da Isoelectric Point: 5.2703
>T200012 WP_212136808.1 NZ_CP073674:1243603-1244178 [Burkholderia cenocepacia]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPDDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIEVDGYLEILLRQGLVQTTKVLATYRTIL
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPDDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIEVDGYLEILLRQGLVQTTKVLATYRTIL
Download Length: 576 bp
>T200012 NZ_CP097683:c4921136-4920852 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA
Antitoxin
Download Length: 157 a.a. Molecular weight: 17245.62 Da Isoelectric Point: 6.3803
>AT200012 WP_003050245.1 NZ_CP073674:1243136-1243606 [Burkholderia cenocepacia]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE
Download Length: 471 bp
>AT200012 NZ_CP097683:c4921368-4921126 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|