Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/PemK-MazE |
| Location | 792936..793468 | Replicon | chromosome |
| Accession | NZ_CP073674 | ||
| Organism | Burkholderia cenocepacia strain toggle4 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | - |
| Locus tag | KEH58_RS03670 | Protein ID | WP_058902188.1 |
| Coordinates | 792936..793259 (-) | Length | 108 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | B4EDC7 |
| Locus tag | KEH58_RS03675 | Protein ID | WP_012492929.1 |
| Coordinates | 793256..793468 (-) | Length | 71 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KEH58_RS03640 (KEH58_03640) | 787946..788779 | - | 834 | WP_034200961.1 | class II glutamine amidotransferase | - |
| KEH58_RS03645 (KEH58_03645) | 788980..789309 | - | 330 | WP_006484989.1 | carboxymuconolactone decarboxylase family protein | - |
| KEH58_RS03650 (KEH58_03650) | 789439..790386 | + | 948 | WP_212136735.1 | AraC family transcriptional regulator | - |
| KEH58_RS03655 (KEH58_03655) | 790490..790933 | + | 444 | WP_011544671.1 | inner membrane protein YiaA | - |
| KEH58_RS03660 (KEH58_03660) | 791056..791967 | - | 912 | WP_249212171.1 | relaxase/mobilization nuclease domain-containing protein | - |
| KEH58_RS36310 | 792092..792409 | - | 318 | WP_226245292.1 | hypothetical protein | - |
| KEH58_RS03670 (KEH58_03670) | 792936..793259 | - | 324 | WP_058902188.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| KEH58_RS03675 (KEH58_03675) | 793256..793468 | - | 213 | WP_012492929.1 | antitoxin MazE family protein | Antitoxin |
| KEH58_RS03680 (KEH58_03680) | 793638..794906 | + | 1269 | WP_077613735.1 | IS256-like element ISBcen18 family transposase | - |
| KEH58_RS03685 (KEH58_03685) | 794998..795450 | - | 453 | WP_006484947.1 | hypothetical protein | - |
| KEH58_RS03690 (KEH58_03690) | 795518..795913 | - | 396 | WP_212136737.1 | hypothetical protein | - |
| KEH58_RS03695 (KEH58_03695) | 796052..796372 | + | 321 | WP_012492928.1 | helix-turn-helix transcriptional regulator | - |
| KEH58_RS03705 (KEH58_03705) | 796799..797548 | - | 750 | WP_125332782.1 | tol-pal system protein YbgF | - |
| KEH58_RS03710 (KEH58_03710) | 797568..798080 | - | 513 | WP_006484980.1 | peptidoglycan-associated lipoprotein Pal | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 793626..794906 | 1280 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 108 a.a. Molecular weight: 11666.79 Da Isoelectric Point: 8.9366
>T200011 WP_058902188.1 NZ_CP073674:c793259-792936 [Burkholderia cenocepacia]
MNRGSIVTVALQGDFGKARPALVVQSDLFAEHPSVTLLLMSSAMVDAPLIRITVLPSEQNGLRMPSQIAVDKMFTVRREK
IGRPIGHLEDELMVAVNRSLLVFLGLA
MNRGSIVTVALQGDFGKARPALVVQSDLFAEHPSVTLLLMSSAMVDAPLIRITVLPSEQNGLRMPSQIAVDKMFTVRREK
IGRPIGHLEDELMVAVNRSLLVFLGLA
Download Length: 324 bp
>T200011 NZ_CP097683:c4819320-4818787 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
Antitoxin
Download Length: 71 a.a. Molecular weight: 8025.99 Da Isoelectric Point: 5.5492
>AT200011 WP_012492929.1 NZ_CP073674:c793468-793256 [Burkholderia cenocepacia]
MAATTSERVRIHRENLRAAGLRPIQIWVPDVRQPGFADECARQSRMVHQSIDENDLLDFIEQVTDLGHSQ
MAATTSERVRIHRENLRAAGLRPIQIWVPDVRQPGFADECARQSRMVHQSIDENDLLDFIEQVTDLGHSQ
Download Length: 213 bp
>AT200011 NZ_CP097683:c4819597-4819331 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|