Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 3563671..3564205 Replicon chromosome
Accession NZ_CP073673
Organism Burkholderia cenocepacia strain toggle2

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag KEH56_RS35955 Protein ID WP_021033200.1
Coordinates 3563671..3563970 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag KEH56_RS35960 Protein ID WP_021033199.1
Coordinates 3563960..3564205 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KEH56_RS35935 (KEH56_35935) 3560531..3561261 + 731 Protein_3280 uroporphyrinogen-III C-methyltransferase -
KEH56_RS35940 (KEH56_35940) 3561258..3561635 + 378 WP_006496449.1 cobalamin biosynthesis protein -
KEH56_RS35945 (KEH56_35945) 3561671..3562273 + 603 WP_006476035.1 cob(I)yrinic acid a,c-diamide adenosyltransferase -
KEH56_RS35950 (KEH56_35950) 3562276..3563580 + 1305 WP_125333102.1 cobyrinate a,c-diamide synthase -
KEH56_RS35955 (KEH56_35955) 3563671..3563970 - 300 WP_021033200.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KEH56_RS35960 (KEH56_35960) 3563960..3564205 - 246 WP_021033199.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
KEH56_RS35965 (KEH56_35965) 3564320..3565483 - 1164 WP_059723573.1 M20 aminoacylase family protein -
KEH56_RS35970 (KEH56_35970) 3565641..3566657 - 1017 WP_034201946.1 GNAT family N-acetyltransferase -
KEH56_RS35975 (KEH56_35975) 3566657..3567496 - 840 WP_034201792.1 N(5)-hydroxyornithine transformylase PvdF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-94)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11720.37 Da        Isoelectric Point: 6.9677

>T200009 WP_021033200.1 NZ_CP073673:c3563970-3563671 [Burkholderia cenocepacia]
MAVKGRQLRLTPLAECDLEDIWRYTAEHWSPEQAEHYYRDLIGTMEALARGKKAGRICVVRDGYFRYPAGSHVVFYRETD
ETIDVIRVLHQRMDIERHL

Download         Length: 300 bp

>T200009 NZ_CP097683:c2820361-2819039 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCTGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8708.68 Da        Isoelectric Point: 7.3196

>AT200009 WP_021033199.1 NZ_CP073673:c3564205-3563960 [Burkholderia cenocepacia]
MSRNTSVSLGDHFAEFVDAQVRSGRYGSASDVVRAGLRLLESHETQMRALQEALKAGEGSGTPKPFDSEAFLARMRATHG
G

Download         Length: 246 bp

>AT200009 NZ_CP097683:c2820627-2820361 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References