Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 2790147..2790679 Replicon chromosome
Accession NZ_CP073673
Organism Burkholderia cenocepacia strain toggle2

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag KEH56_RS32250 Protein ID WP_212268290.1
Coordinates 2790147..2790470 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag KEH56_RS32255 Protein ID WP_012327974.1
Coordinates 2790467..2790679 (-) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KEH56_RS32220 (KEH56_32220) 2785154..2785987 - 834 WP_212268620.1 class II glutamine amidotransferase -
KEH56_RS32225 (KEH56_32225) 2786191..2786520 - 330 WP_006484989.1 carboxymuconolactone decarboxylase family protein -
KEH56_RS32230 (KEH56_32230) 2786650..2787597 + 948 WP_212268281.1 AraC family transcriptional regulator -
KEH56_RS32235 (KEH56_32235) 2787701..2788144 + 444 WP_212268284.1 inner membrane protein YiaA -
KEH56_RS32240 (KEH56_32240) 2788267..2789301 - 1035 WP_212268286.1 relaxase/mobilization nuclease domain-containing protein -
KEH56_RS37510 2789303..2789620 - 318 WP_226245292.1 hypothetical protein -
KEH56_RS32250 (KEH56_32250) 2790147..2790470 - 324 WP_212268290.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KEH56_RS32255 (KEH56_32255) 2790467..2790679 - 213 WP_012327974.1 antitoxin MazE family protein Antitoxin
KEH56_RS32260 (KEH56_32260) 2790792..2791271 - 480 WP_011694172.1 hypothetical protein -
KEH56_RS32265 (KEH56_32265) 2791339..2791734 - 396 WP_012327976.1 hypothetical protein -
KEH56_RS32270 (KEH56_32270) 2791875..2792195 + 321 WP_212268292.1 helix-turn-helix transcriptional regulator -
KEH56_RS32280 (KEH56_32280) 2792622..2793371 - 750 WP_006484965.1 tol-pal system protein YbgF -
KEH56_RS32285 (KEH56_32285) 2793391..2793903 - 513 WP_006484980.1 peptidoglycan-associated lipoprotein Pal -
KEH56_RS32290 (KEH56_32290) 2793921..2795216 - 1296 WP_012492927.1 Tol-Pal system beta propeller repeat protein TolB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-103)

Antitoxin

Antitoxin MazE-like

(7-67)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11666.79 Da        Isoelectric Point: 8.9366

>T200008 WP_212268290.1 NZ_CP073673:c2790470-2790147 [Burkholderia cenocepacia]
MNRGSIVTVALQGDFGKARPALVVQSDLFAEHPSVTLLLMSSAMVDAPLIRITVVPSEQNGLRMPSQIAVDKMFTVRREK
IGRPIGHLEDELMVAINRSLLVFLGLA

Download         Length: 324 bp

>T200008 NZ_CP097683:2090918-2091020 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7997.94 Da        Isoelectric Point: 5.5492

>AT200008 WP_012327974.1 NZ_CP073673:c2790679-2790467 [Burkholderia cenocepacia]
MAATTSERVRIHRENLRAAGLRPIQIWVPDVRQPGFADECARQSRMVHQSIDENDLLDFIEQATDLGHSQ

Download         Length: 213 bp

>AT200008 NZ_CP097683:c2091027-2090882 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References