Detailed information of TA system TA200007

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-vagC/VapC-VagC
• Location: 2120787..2121424
• Replicon: chromosome
• Accession: NZ_CP073673
• Organism: Burkholderia cenocepacia strain toggle2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: KEH56_RS29090
• Protein ID: WP_058902008.1
• Coordinates: 2121023..2121424 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: A0A364GPY9
• Locus tag: KEH56_RS29085
• Protein ID: WP_034201144.1
• Coordinates: 2120787..2121023 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KEH56_RS29065 (KEH56_29065)	2116163..2117179	+	1017	WP_006493582.1	helix-turn-helix domain-containing protein	-
KEH56_RS29070 (KEH56_29070)	2117274..2118371	-	1098	WP_062884188.1	hypothetical protein	-
KEH56_RS29075 (KEH56_29075)	2118368..2120071	-	1704	WP_059721116.1	thiamine pyrophosphate-binding protein	-
KEH56_RS29080 (KEH56_29080)	2120440..2120669	+	230	Protein_1931	type II toxin-antitoxin system RelE/ParE family toxin	-
KEH56_RS29085 (KEH56_29085)	2120787..2121023	+	237	WP_034201144.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
KEH56_RS29090 (KEH56_29090)	2121023..2121424	+	402	WP_058902008.1	type II toxin-antitoxin system VapC family toxin	Toxin
KEH56_RS29095 (KEH56_29095)	2121491..2122879	-	1389	WP_006485681.1	L-serine ammonia-lyase	-
KEH56_RS29100 (KEH56_29100)	2122910..2124040	-	1131	WP_230391081.1	alginate lyase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-120)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 15043.22 Da
• Isoelectric Point: 5.6634

>T200007 WP_058902008.1 NZ_CP073673:2121023-2121424 [Burkholderia cenocepacia]
MPRFMLDTNMCIYLMKNQPEQVARRFAQCYTGDVVMSAITYAELEYGLTACANPARERRHLAALIEDIPVAPFDAAAAQA
YGPVREATRERKKDHLDKLIAAHAVSLDVVLVTNNERDFVSYPGLRLENWLND

Nucleotide

• Length: 402 bp

>T200007 NZ_CP097683:934527-934934 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8982.15 Da
• Isoelectric Point: 6.4701

>AT200007 WP_034201144.1 NZ_CP073673:2120787-2121023 [Burkholderia cenocepacia]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERVGDEIRIRPMRRPLTQVLAKFAKFGPDFMADGRGDHEQAEREGL

Nucleotide

• Length: 237 bp

>AT200007 NZ_CP097683:934280-934546 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A364GPY9