Detailed information of TA system TA200006

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 819046..819602
• Replicon: chromosome
• Accession: NZ_CP073673
• Organism: Burkholderia cenocepacia strain toggle2

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: KEH56_RS23030
• Protein ID: WP_229202334.1
• Coordinates: 819046..819297 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: M4UBZ0
• Locus tag: KEH56_RS23035
• Protein ID: WP_004541313.1
• Coordinates: 819324..819602 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KEH56_RS23005 (KEH56_23005)	814531..815052	+	522	WP_212267855.1	hypothetical protein	-
KEH56_RS23010 (KEH56_23010)	815282..817480	+	2199	WP_212267857.1	AAA family ATPase	-
KEH56_RS23015 (KEH56_23015)	817522..818181	-	660	WP_212267859.1	hypothetical protein	-
KEH56_RS23020 (KEH56_23020)	818286..818534	-	249	WP_059478629.1	hypothetical protein	-
KEH56_RS37740	818602..818736	-	135	WP_011051575.1	hypothetical protein	-
KEH56_RS23025 (KEH56_23025)	818729..819043	-	315	WP_023872355.1	hypothetical protein	-
KEH56_RS23030 (KEH56_23030)	819046..819297	-	252	WP_229202334.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KEH56_RS23035 (KEH56_23035)	819324..819602	-	279	WP_004541313.1	CopG family ribbon-helix-helix protein	Antitoxin
KEH56_RS23040 (KEH56_23040)	819574..821709	-	2136	WP_249214476.1	relaxase/mobilization nuclease domain-containing protein	-
KEH56_RS23045 (KEH56_23045)	821712..821981	-	270	WP_201455650.1	plasmid mobilization protein MobA	-
KEH56_RS23050 (KEH56_23050)	822471..822728	+	258	WP_041195370.1	hypothetical protein	-
KEH56_RS23055 (KEH56_23055)	822695..824131	-	1437	WP_212267861.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	816173..850309	34136

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-81)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9594.91 Da
• Isoelectric Point: 9.9718

>T200006 WP_229202334.1 NZ_CP073673:c819297-819046 [Burkholderia cenocepacia]
MQRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLPEQYREWLIDFGDSGYVARYRLDGDTVTILAVRHQKE
AGY

Nucleotide

• Length: 252 bp

>T200006 NZ_CP097683:770829-771005 [Klebsiella pneumoniae]
GTGAAGCAAAGCGAGTTGAGGCGTTGGCTTGCAGCTCAAGGGGCAGAATTTAAAGATGGTACTAACCACTTGAAAATCTA
TCTCAACGGCAAGCAAACGGTAATGCCGAGACATCCGGGGAAGGAAATACCGGAACCGCTGAGGAAGGCAATTCTTAAGC
AACTCGGCATCAAATAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10810.11 Da
• Isoelectric Point: 4.9736

>AT200006 WP_004541313.1 NZ_CP073673:c819602-819324 [Burkholderia cenocepacia]
MVTATSIKLDDELKGRVQHLAEARRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT200006 NZ_CP097683:771053-771460 [Klebsiella pneumoniae]
ATGCGATACCCGGTAATTTTTGAGCATGACGAAACCGGCTGGGCGGTATTCTTTCCGGATATCCCAGAGGCAATGACGGG
AGGAGAGACCAGGGAGGAAGCGTTAGAAATGGCGCAAGATGCCCTGGTGACGGCGTTTGATTTTTACTTTGACGACCGCC
GGGAGATTCCCGCTCCATCAGCAGAAGGTGATGCGTTTGTTGAGGTTCCGGCCAGCGTGGCAGCTAAAGTATTGCTGTTA
AACCGTCTGGTCAGCACCAACACCAGCAATGCTGATCTCGCCCGCATGATTAACACGCGCCCACAGGAAGTGCAGCGCAT
CGTGTCTCTTGGTCACAGCACCAAAATCGATACGATCCAAAAAGCGCTATCAGCGTTGGGGCAAAAGATGGAAATTATCG
TCCACTAA

Structures

Antitoxin

• AlphaFold DB: M4UBZ0