Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1-VagC |
| Location | 64958..65607 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP073671 | ||
| Organism | Burkholderia cenocepacia strain toggle2 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | KEH56_RS18795 | Protein ID | WP_175914695.1 |
| Coordinates | 65197..65607 (+) | Length | 137 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | A0A103EQ81 |
| Locus tag | KEH56_RS18790 | Protein ID | WP_059569609.1 |
| Coordinates | 64958..65200 (+) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KEH56_RS18770 (KEH56_18770) | 60138..60995 | - | 858 | WP_212267607.1 | plasmid replication initiator TrfA | - |
| KEH56_RS18775 (KEH56_18775) | 61751..62716 | - | 966 | WP_249214460.1 | chromosome partitioning protein ParB | - |
| KEH56_RS18780 (KEH56_18780) | 62716..63387 | - | 672 | WP_089430219.1 | AAA family ATPase | - |
| KEH56_RS37715 | 63887..64015 | + | 129 | WP_283093732.1 | hypothetical protein | - |
| KEH56_RS37330 | 64226..64471 | + | 246 | WP_249214461.1 | hypothetical protein | - |
| KEH56_RS18790 (KEH56_18790) | 64958..65200 | + | 243 | WP_059569609.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
| KEH56_RS18795 (KEH56_18795) | 65197..65607 | + | 411 | WP_175914695.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| KEH56_RS18800 (KEH56_18800) | 65681..65881 | + | 201 | WP_212267609.1 | hypothetical protein | - |
| KEH56_RS18805 (KEH56_18805) | 66231..66476 | + | 246 | WP_212267611.1 | hypothetical protein | - |
| KEH56_RS18810 (KEH56_18810) | 66494..66673 | + | 180 | WP_212267613.1 | hypothetical protein | - |
| KEH56_RS18815 (KEH56_18815) | 66766..67074 | + | 309 | WP_212267615.1 | hypothetical protein | - |
| KEH56_RS18820 (KEH56_18820) | 67315..67569 | + | 255 | WP_212267496.1 | hypothetical protein | - |
| KEH56_RS18825 (KEH56_18825) | 67638..68255 | + | 618 | WP_212267499.1 | hypothetical protein | - |
| KEH56_RS18830 (KEH56_18830) | 68291..68545 | + | 255 | WP_212267503.1 | hypothetical protein | - |
| KEH56_RS18835 (KEH56_18835) | 68555..69232 | + | 678 | WP_212267506.1 | hypothetical protein | - |
| KEH56_RS18840 (KEH56_18840) | 69279..69620 | + | 342 | WP_212267508.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..134189 | 134189 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 137 a.a. Molecular weight: 14828.14 Da Isoelectric Point: 5.8355
>T200005 WP_175914695.1 NZ_CP073671:65197-65607 [Burkholderia cenocepacia]
MTLYLLDTNILSNVIRDPRGACATRIGQMPPEQVCTSIIVAAELRFGVWKRGSSTLAQRVEQLLASLTVLPLQPDADRCY
GRLRADLEKQGQLIGANDMLIAAHALAVDAVLVTDNTAEFTRVSGLPVENWLRPAT
MTLYLLDTNILSNVIRDPRGACATRIGQMPPEQVCTSIIVAAELRFGVWKRGSSTLAQRVEQLLASLTVLPLQPDADRCY
GRLRADLEKQGQLIGANDMLIAAHALAVDAVLVTDNTAEFTRVSGLPVENWLRPAT
Download Length: 411 bp
>T200005 NZ_CP097683:742348-742833 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA
Antitoxin
Download Length: 81 a.a. Molecular weight: 9350.59 Da Isoelectric Point: 4.6856
>AT200005 WP_059569609.1 NZ_CP073671:64958-65200 [Burkholderia cenocepacia]
MPTHDTRHARLFRNGRSQAVRIPREFELPVSEVTIHREGRRLIIEPVEAAPLRELFAQWTPLDETFPDIEDLPPEPVDIE
MPTHDTRHARLFRNGRSQAVRIPREFELPVSEVTIHREGRRLIIEPVEAAPLRELFAQWTPLDETFPDIEDLPPEPVDIE
Download Length: 243 bp
>AT200005 NZ_CP097683:742058-742351 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|