Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1798680..1799300 Replicon chromosome
Accession NZ_CP073669
Organism Burkholderia cenocepacia strain toggle2

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KEH56_RS07765 Protein ID WP_109342363.1
Coordinates 1798680..1798997 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KEH56_RS07770 Protein ID WP_006490972.1
Coordinates 1799001..1799300 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KEH56_RS07755 (KEH56_07755) 1795189..1796622 - 1434 WP_006490987.1 aldehyde dehydrogenase family protein -
KEH56_RS07760 (KEH56_07760) 1796651..1798291 - 1641 WP_006490980.1 acetolactate synthase large subunit -
KEH56_RS07765 (KEH56_07765) 1798680..1798997 + 318 WP_109342363.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KEH56_RS07770 (KEH56_07770) 1799001..1799300 + 300 WP_006490972.1 putative addiction module antidote protein Antitoxin
KEH56_RS07775 (KEH56_07775) 1799349..1800635 - 1287 WP_212266225.1 DUF445 domain-containing protein -
KEH56_RS07780 (KEH56_07780) 1800745..1801965 - 1221 WP_212266227.1 anthranilate 1,2-dioxygenase system ferredoxin--NAD(+) reductase -
KEH56_RS07785 (KEH56_07785) 1801955..1802281 - 327 WP_006496019.1 anthranilate 1,2-dioxygenase ferredoxin subunit AndAb -
KEH56_RS07790 (KEH56_07790) 1802317..1802793 - 477 WP_006490977.1 anthranilate 1,2-dioxygenase small subunit AndAd -
KEH56_RS07795 (KEH56_07795) 1802809..1804080 - 1272 WP_212266229.1 anthranilate 1,2-dioxygenase large subunit AndAc -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(9-100)

Antitoxin

Uncharacterized protein HI1420

(4-96)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11826.55 Da        Isoelectric Point: 7.2769

>T200003 WP_109342363.1 NZ_CP073669:1798680-1798997 [Burkholderia cenocepacia]
MPYSPPAFSIRTTDVFDAWFAGLPDRLAKRRIQARIDRLSMGNPGDWKSAGSPVVEMRIDHGPGYRVYDVRRETIWVILL
CGGDQSTQLADIRAAHAMLAHLDME

Download         Length: 318 bp

>T200003 NZ_CP097683:328889-329257 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10608.04 Da        Isoelectric Point: 6.4771

>AT200003 WP_006490972.1 NZ_CP073669:1799001-1799300 [Burkholderia cenocepacia]
MDKIKTRPWDSAEHLKTEDDMADYFDACLQEAGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAAA

Download         Length: 300 bp

>AT200003 NZ_CP097683:328671-328892 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References