Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1443036..1443682 Replicon chromosome
Accession NZ_CP073669
Organism Burkholderia cenocepacia strain toggle2

Toxin (Protein)


Gene name vapC Uniprot ID A0A1V2W4R9
Locus tag KEH56_RS06230 Protein ID WP_062885461.1
Coordinates 1443036..1443443 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B4EGU8
Locus tag KEH56_RS06235 Protein ID WP_006491146.1
Coordinates 1443440..1443682 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KEH56_RS06215 (KEH56_06215) 1438931..1439512 - 582 WP_058902967.1 hypothetical protein -
KEH56_RS37630 (KEH56_06220) 1439509..1440237 - 729 WP_058903588.1 methyl-accepting chemotaxis protein -
KEH56_RS06225 (KEH56_06225) 1440260..1442635 - 2376 WP_034202502.1 MCP four helix bundle domain-containing protein -
KEH56_RS06230 (KEH56_06230) 1443036..1443443 - 408 WP_062885461.1 type II toxin-antitoxin system VapC family toxin Toxin
KEH56_RS06235 (KEH56_06235) 1443440..1443682 - 243 WP_006491146.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
KEH56_RS06240 (KEH56_06240) 1443941..1444624 + 684 WP_080331177.1 phospholipase -
KEH56_RS06245 (KEH56_06245) 1444698..1446203 - 1506 WP_212267170.1 amino acid permease -
KEH56_RS06250 (KEH56_06250) 1446281..1447687 - 1407 WP_034202505.1 aspartate ammonia-lyase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

SpoVT-AbrB domain

(7-49)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14936.05 Da        Isoelectric Point: 6.2179

>T200002 WP_062885461.1 NZ_CP073669:c1443443-1443036 [Burkholderia cenocepacia]
MKFLLDTNAVIAILKGEPAILARLHAWHPADFGIPAIVAHELYYGAYKSQRAAANVARVDALQFEVVSFDTEDAQHAGEI
RAHLIAAGTPIGPYDALIAGQARARQLVLVTHNVREFERVPRLQFEDWLAEPRAD

Download         Length: 408 bp

>T200002 NZ_CP097682:25204-25353 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.02 Da        Isoelectric Point: 5.0197

>AT200002 WP_006491146.1 NZ_CP073669:c1443682-1443440 [Burkholderia cenocepacia]
MDTAKLFKHGGSQAVRLPKDFRFDTAEVRIRRHGAAVILEPMPQDWAWLAPLIGPVDADFEAAATTQPSAQERSGLDVFE

Download         Length: 243 bp

>AT200002 NZ_CP097682:c25159-25100 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1V2W4R9

Antitoxin

Source ID Structure
AlphaFold DB B4EGU8

References