Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2686123..2686642 Replicon chromosome
Accession NZ_CP073667
Organism Burkholderia contaminans strain toggle1

Toxin (Protein)


Gene name relE Uniprot ID A0A1E3FLI5
Locus tag KEH59_RS38985 Protein ID WP_039349649.1
Coordinates 2686123..2686404 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A4V2WFY1
Locus tag KEH59_RS38990 Protein ID WP_039349647.1
Coordinates 2686394..2686642 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KEH59_RS38965 (KEH59_38965) 2681778..2682476 - 699 WP_039349658.1 MgtC/SapB family protein -
KEH59_RS38970 (KEH59_38970) 2682591..2683700 + 1110 WP_039349656.1 AGE family epimerase/isomerase -
KEH59_RS38975 (KEH59_38975) 2683673..2685292 - 1620 WP_039349654.1 methyl-accepting chemotaxis protein -
KEH59_RS38980 (KEH59_38980) 2685562..2686005 + 444 WP_011353771.1 PaaI family thioesterase -
KEH59_RS38985 (KEH59_38985) 2686123..2686404 - 282 WP_039349649.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KEH59_RS38990 (KEH59_38990) 2686394..2686642 - 249 WP_039349647.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KEH59_RS38995 (KEH59_38995) 2686784..2687836 - 1053 WP_039349645.1 CaiB/BaiF CoA-transferase family protein -
KEH59_RS39000 (KEH59_39000) 2688020..2689210 - 1191 WP_039349643.1 2-methylaconitate cis-trans isomerase PrpF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-78)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10986.88 Da        Isoelectric Point: 10.7091

>T199995 WP_039349649.1 NZ_CP073667:c2686404-2686123 [Burkholderia contaminans]
MTFELAFLEPALKEWKKLDRTVRDQFKSRLAERLENPRIPSAKLQGHPDRYKIKLRSVGYRLVYEVRDSEVLVLVVAVGR
RERDAVYLAAMKR

Download         Length: 282 bp

>T199995 NZ_CP097679:c4782693-4782160 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9031.44 Da        Isoelectric Point: 5.6792

>AT199995 WP_039349647.1 NZ_CP073667:c2686642-2686394 [Burkholderia contaminans]
MPHTILANVTASVSELKRNPMGTVAAGEGFPVAILNHNEPAFYCIPAKTWEAMVERLEDIEDNALADKRAKEKVVKVKLN
DL

Download         Length: 249 bp

>AT199995 NZ_CP097679:c4782970-4782704 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E3FLI5

Antitoxin

Source ID Structure
AlphaFold DB A0A4V2WFY1

References