Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/HTH_IclR(antitoxin) |
| Location | 1644667..1646417 | Replicon | chromosome |
| Accession | NZ_CP073667 | ||
| Organism | Burkholderia contaminans strain toggle1 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | A0A1E3FSX8 |
| Locus tag | KEH59_RS34385 | Protein ID | WP_039344096.1 |
| Coordinates | 1645521..1646417 (-) | Length | 299 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | A0A1E3FSY5 |
| Locus tag | KEH59_RS34380 | Protein ID | WP_039344097.1 |
| Coordinates | 1644667..1645524 (-) | Length | 286 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KEH59_RS34360 (KEH59_34360) | 1639830..1641320 | - | 1491 | WP_039344105.1 | aldehyde dehydrogenase | - |
| KEH59_RS34365 (KEH59_34365) | 1641393..1642220 | - | 828 | WP_039344103.1 | aspartate dehydrogenase | - |
| KEH59_RS34370 (KEH59_34370) | 1642213..1643880 | - | 1668 | WP_039344101.1 | thiamine pyrophosphate-binding protein | - |
| KEH59_RS34375 (KEH59_34375) | 1643873..1644670 | - | 798 | WP_039344099.1 | SDR family oxidoreductase | - |
| KEH59_RS34380 (KEH59_34380) | 1644667..1645524 | - | 858 | WP_039344097.1 | IclR family transcriptional regulator | Antitoxin |
| KEH59_RS34385 (KEH59_34385) | 1645521..1646417 | - | 897 | WP_039344096.1 | alpha/beta fold hydrolase | Toxin |
| KEH59_RS34390 (KEH59_34390) | 1646436..1646963 | - | 528 | WP_039344094.1 | cupin domain-containing protein | - |
| KEH59_RS34395 (KEH59_34395) | 1647001..1647771 | - | 771 | WP_039344092.1 | SDR family oxidoreductase | - |
| KEH59_RS34400 (KEH59_34400) | 1647764..1648840 | - | 1077 | WP_039344090.1 | aromatic ring-hydroxylating dioxygenase subunit alpha | - |
| KEH59_RS34405 (KEH59_34405) | 1648893..1649204 | - | 312 | WP_039344088.1 | hypothetical protein | - |
| KEH59_RS34410 (KEH59_34410) | 1649206..1649523 | - | 318 | WP_011354710.1 | non-heme iron oxygenase ferredoxin subunit | - |
| KEH59_RS34415 (KEH59_34415) | 1649968..1651047 | + | 1080 | WP_039344086.1 | porin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 299 a.a. Molecular weight: 30700.99 Da Isoelectric Point: 8.0624
>T199994 WP_039344096.1 NZ_CP073667:c1646417-1645521 [Burkholderia contaminans]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAHHAGRALPVVLLHGIGSGAASWVRQLDTLGASRRVLAW
DAPGYGVSTPVHGASPAATDYAASLNAWLEALGIERCVLVGHSLGAIIAGGLIRVMPARIAGLLLVSPAGGYGSAPAETR
DARRDARLAMLAELGPAGLAEQRSGNMLSGFANEDARAWVRWNMARIVPAGYAQATQLLANADLATDLAGFRGRTAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAVYSALIDAFCRQCDQQRGLA
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAHHAGRALPVVLLHGIGSGAASWVRQLDTLGASRRVLAW
DAPGYGVSTPVHGASPAATDYAASLNAWLEALGIERCVLVGHSLGAIIAGGLIRVMPARIAGLLLVSPAGGYGSAPAETR
DARRDARLAMLAELGPAGLAEQRSGNMLSGFANEDARAWVRWNMARIVPAGYAQATQLLANADLATDLAGFRGRTAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAVYSALIDAFCRQCDQQRGLA
Download Length: 897 bp
>T199994 NZ_CP097679:4168560-4168778 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA
Antitoxin
Download Length: 286 a.a. Molecular weight: 31463.03 Da Isoelectric Point: 6.7661
>AT199994 WP_039344097.1 NZ_CP073667:c1645524-1644667 [Burkholderia contaminans]
MNEPLQRPELENGKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQAPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELHALYPEGTLNRMTNATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQRIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR
MNEPLQRPELENGKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQAPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELHALYPEGTLNRMTNATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQRIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR
Download Length: 858 bp
>AT199994 NZ_CP097679:4168159-4168533 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1E3FSX8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1E3FSY5 |