Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 486733..487374 Replicon chromosome
Accession NZ_CP073667
Organism Burkholderia contaminans strain toggle1

Toxin (Protein)


Gene name relE Uniprot ID A0A1E3FZX6
Locus tag KEH59_RS29335 Protein ID WP_039344753.1
Coordinates 487036..487374 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1J9PWC2
Locus tag KEH59_RS29330 Protein ID WP_039344756.1
Coordinates 486733..487032 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KEH59_RS29305 (KEH59_29305) 481896..483167 + 1272 WP_039344770.1 anthranilate 1,2-dioxygenase large subunit AndAc -
KEH59_RS29310 (KEH59_29310) 483182..483670 + 489 WP_011355917.1 anthranilate 1,2-dioxygenase small subunit AndAd -
KEH59_RS29315 (KEH59_29315) 483691..484017 + 327 WP_039344765.1 anthranilate 1,2-dioxygenase ferredoxin subunit AndAb -
KEH59_RS29320 (KEH59_29320) 484007..485227 + 1221 WP_039344761.1 anthranilate 1,2-dioxygenase system ferredoxin--NAD(+) reductase -
KEH59_RS29325 (KEH59_29325) 485398..486684 + 1287 WP_039344759.1 DUF445 domain-containing protein -
KEH59_RS29330 (KEH59_29330) 486733..487032 - 300 WP_039344756.1 putative addiction module antidote protein Antitoxin
KEH59_RS29335 (KEH59_29335) 487036..487374 - 339 WP_039344753.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KEH59_RS29340 (KEH59_29340) 487706..489346 + 1641 WP_039344750.1 acetolactate synthase large subunit -
KEH59_RS29345 (KEH59_29345) 489376..490809 + 1434 WP_039344747.1 aldehyde dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(16-107)

Antitoxin

Uncharacterized protein HI1420

(6-93)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12583.47 Da        Isoelectric Point: 9.5691

>T199992 WP_039344753.1 NZ_CP073667:c487374-487036 [Burkholderia contaminans]
MVDILQSMPYSAPTFSIRTTGVFDTWFAGLQDRVAKRRIQARIDRLSMGNPGDWKSAGSPVVEMRIDHGPGYRVYYVRRG
TIWVILLCGGDKSSQQADIRAAHAMLAHLDME

Download         Length: 339 bp

>T199992 NZ_CP097679:2023196-2023298 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10649.01 Da        Isoelectric Point: 6.3217

>AT199992 WP_039344756.1 NZ_CP073667:c487032-486733 [Burkholderia contaminans]
MDKISTRPWDSADHLKTEDDMADYFEACLQEAGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGSKAHA

Download         Length: 300 bp

>AT199992 NZ_CP097679:c2023305-2023160 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E3FZX6

Antitoxin

Source ID Structure
AlphaFold DB A0A1J9PWC2

References