Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 3481938..3482575 Replicon chromosome
Accession NZ_CP073665
Organism Burkholderia contaminans strain toggle1

Toxin (Protein)


Gene name vapC Uniprot ID A0A228K4S8
Locus tag KEH59_RS25030 Protein ID WP_039351354.1
Coordinates 3481938..3482339 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A1E3FXY0
Locus tag KEH59_RS25035 Protein ID WP_039351357.1
Coordinates 3482339..3482575 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KEH59_RS25020 (KEH59_25020) 3479345..3480448 + 1104 WP_223274380.1 alginate lyase family protein -
KEH59_RS25025 (KEH59_25025) 3480479..3481867 + 1389 WP_039351351.1 L-serine ammonia-lyase -
KEH59_RS25030 (KEH59_25030) 3481938..3482339 - 402 WP_039351354.1 type II toxin-antitoxin system VapC family toxin Toxin
KEH59_RS25035 (KEH59_25035) 3482339..3482575 - 237 WP_039351357.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
KEH59_RS25040 (KEH59_25040) 3482936..3484639 + 1704 WP_039351360.1 thiamine pyrophosphate-binding protein -
KEH59_RS25045 (KEH59_25045) 3484636..3485733 + 1098 WP_039351363.1 ADP-heptose--LPS heptosyltransferase -
KEH59_RS25050 (KEH59_25050) 3485851..3486882 - 1032 WP_039351365.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14880.98 Da        Isoelectric Point: 4.7249

>T199991 WP_039351354.1 NZ_CP073665:c3482339-3481938 [Burkholderia contaminans]
MPRYMLDTNMCIYLMKNQPEQVARRFAQCYTGDVVMSAITYAELEYGVAACASPARERGNLAALIDDIPVAPFDVAAAQA
YGPVREATRERKKDHLDKLIAAHAVSLDVVLVTNNERDFVSYPGLRLENWLDD

Download         Length: 402 bp

>T199991 NZ_CP097679:878477-878884 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9008.13 Da        Isoelectric Point: 6.4720

>AT199991 WP_039351357.1 NZ_CP073665:c3482575-3482339 [Burkholderia contaminans]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERIGDEIRIRPARRPLTRVLEKFAKFGPDFMADGRGDHEQADREGL

Download         Length: 237 bp

>AT199991 NZ_CP097679:878230-878496 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A228K4S8

Antitoxin

Source ID Structure
AlphaFold DB A0A1E3FXY0

References