Detailed information of TA system TA199990

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VagC(antitoxin)
• Location: 1714600..1715024
• Replicon: chromosome
• Accession: NZ_CP073665
• Organism: Burkholderia contaminans strain toggle1

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: -
• Locus tag: KEH59_RS42850
• Protein ID: WP_223274361.1
• Coordinates: 1714600..1714761 (-)
• Length: 54 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: A0A1E3FFT1
• Locus tag: KEH59_RS16855
• Protein ID: WP_046196769.1
• Coordinates: 1714758..1715024 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KEH59_RS16825 (KEH59_16825)	1710825..1711064	-	240	WP_232490759.1	type II toxin-antitoxin system RelE/ParE family toxin	-
KEH59_RS16830 (KEH59_16830)	1711110..1711355	-	246	WP_076841742.1	type II toxin-antitoxin system ParD family antitoxin	-
KEH59_RS16835 (KEH59_16835)	1711472..1712635	-	1164	WP_039358627.1	M20 aminoacylase family protein	-
KEH59_RS16840 (KEH59_16840)	1712955..1714043	+	1089	WP_249215684.1	type IV toxin-antitoxin system AbiEi family antitoxin	-
KEH59_RS16845 (KEH59_16845)	1714057..1714296	+	240	Protein_1584	nucleotidyltransferase	-
KEH59_RS42845	1714345..1714572	-	228	WP_223274360.1	hypothetical protein	-
KEH59_RS42850	1714600..1714761	-	162	WP_223274361.1	type II toxin-antitoxin system VapC family toxin	Toxin
KEH59_RS16855 (KEH59_16855)	1714758..1715024	-	267	WP_046196769.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
KEH59_RS16860 (KEH59_16860)	1715274..1716290	-	1017	WP_039358635.1	GNAT family N-acetyltransferase	-
KEH59_RS16865 (KEH59_16865)	1716290..1717129	-	840	WP_039358638.1	N(5)-hydroxyornithine transformylase PvdF	-
KEH59_RS16870 (KEH59_16870)	1717216..1719477	-	2262	WP_039358640.1	TonB-dependent siderophore receptor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• SpoVT-AbrB domain (7-50)

Sequences

Toxin

Protein

• Length: 54 a.a.
• Molecular weight: 5903.95 Da
• Isoelectric Point: 8.5349

>T199990 WP_223274361.1 NZ_CP073665:c1714761-1714600 [Burkholderia contaminans]
VTTLYMLDTSICSFIMRERPPVVLSRLQSCVNAQHRIVVSAITYAEMRFGAAG

Nucleotide

• Length: 162 bp

>T199990 NZ_CP097679:744216-744701 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9629.86 Da
• Isoelectric Point: 4.4819

>AT199990 WP_046196769.1 NZ_CP073665:c1715024-1714758 [Burkholderia contaminans]
MRTVSIFKNARNQAIRIPKDMEFEGVTELEIRREGDTLLLRPVRPTCLSFASEPPADADFLAERPAVIEPGRFDLSDGGG
AAPTESGQ

Nucleotide

• Length: 267 bp

>AT199990 NZ_CP097679:743926-744219 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A1E3FFT1