Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 501406..502001 Replicon chromosome
Accession NZ_CP073664
Organism Burkholderia contaminans strain toggle1

Toxin (Protein)


Gene name chpB Uniprot ID A0A1E3FP25
Locus tag KEH59_RS04405 Protein ID WP_039362634.1
Coordinates 501651..502001 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID A0A0G3Z282
Locus tag KEH59_RS04400 Protein ID WP_039362633.1
Coordinates 501406..501657 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KEH59_RS04385 (KEH59_04385) 496686..497363 + 678 WP_039362629.1 heavy metal response regulator transcription factor -
KEH59_RS04390 (KEH59_04390) 497360..498820 + 1461 WP_039362631.1 heavy metal sensor histidine kinase -
KEH59_RS04395 (KEH59_04395) 499052..500323 - 1272 WP_249215655.1 asparagine synthase C-terminal domain-containing protein -
KEH59_RS42560 500421..500756 - 336 Protein_449 asparagine synthase (glutamine-hydrolyzing) -
KEH59_RS04400 (KEH59_04400) 501406..501657 + 252 WP_039362633.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
KEH59_RS04405 (KEH59_04405) 501651..502001 + 351 WP_039362634.1 type II toxin-antitoxin system ChpB family toxin Toxin
KEH59_RS04410 (KEH59_04410) 502125..503654 - 1530 WP_039362750.1 efflux transporter outer membrane subunit -
KEH59_RS04415 (KEH59_04415) 503686..505146 - 1461 WP_039362635.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12403.30 Da        Isoelectric Point: 10.0752

>T199988 WP_039362634.1 NZ_CP073664:501651-502001 [Burkholderia contaminans]
MVRRVKFERGDIVRVSLNPTVGKEQQGDFRPALVLSPAAFNALGVALVAPITQGGEFARYAGFAVPLSGSGTETQGVALV
NMVRTLDLQARGARKVERAPSEVIEDALARLQTILE

Download         Length: 351 bp

>T199988 NZ_CP097679:328118-328486 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 8948.19 Da        Isoelectric Point: 4.7204

>AT199988 WP_039362633.1 NZ_CP073664:501406-501657 [Burkholderia contaminans]
MELKIQKWGNSAAVRLPAVLLEQIDASVGSSLNADVRPDGVLLSPARRKYSLDELIAQCDPKAPEPADLAAWGESKPVGH
EAW

Download         Length: 252 bp

>AT199988 NZ_CP097679:327900-328121 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E3FP25

Antitoxin

Source ID Structure
AlphaFold DB A0A0G3Z282

References