199983

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2421122..2421638 Replicon chromosome
Accession NZ_CP073661
Organism Pseudomonas sp. JS425

Toxin (Protein)


Gene name relE Uniprot ID F8G1E7
Locus tag KDB76_RS11145 Protein ID WP_003259987.1
Coordinates 2421357..2421638 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID F8G1E6
Locus tag KDB76_RS11140 Protein ID WP_013972043.1
Coordinates 2421122..2421367 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KDB76_RS11120 (KDB76_11120) 2416549..2417091 - 543 WP_038409286.1 WYL domain-containing protein -
KDB76_RS11125 (KDB76_11125) 2417199..2418185 - 987 WP_013972040.1 zinc-binding dehydrogenase -
KDB76_RS11130 (KDB76_11130) 2418548..2419741 + 1194 WP_038409288.1 MFS transporter -
KDB76_RS11135 (KDB76_11135) 2419772..2420878 + 1107 WP_031325095.1 alkene reductase -
KDB76_RS11140 (KDB76_11140) 2421122..2421367 + 246 WP_013972043.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KDB76_RS11145 (KDB76_11145) 2421357..2421638 + 282 WP_003259987.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KDB76_RS11150 (KDB76_11150) 2421677..2422072 - 396 WP_023662326.1 hypothetical protein -
KDB76_RS11155 (KDB76_11155) 2422161..2423069 - 909 WP_038409290.1 LysR family transcriptional regulator -
KDB76_RS11160 (KDB76_11160) 2423361..2424665 + 1305 WP_013972046.1 MFS transporter -
KDB76_RS11165 (KDB76_11165) 2424696..2425937 + 1242 WP_013972047.1 Zn-dependent hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(10-76)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10909.78 Da        Isoelectric Point: 10.7594

>T199983 WP_003259987.1 NZ_CP073661:2421357-2421638 [Pseudomonas sp. JS425]
MTYKLEFLPSALKEWGKLGHTVREQIKKKLAERLQSPKVQADALRDLPNHYKIKLKASGYRLVYRVEDERIVVVVVSVGK
RERSEVYRSAQKR

Download         Length: 282 bp

>T199983 NZ_CP097675:c5358570-5358187 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8779.21 Da        Isoelectric Point: 4.3611

>AT199983 WP_013972043.1 NZ_CP073661:2421122-2421367 [Pseudomonas sp. JS425]
MQNIFADVAVSVSELKKNPSAVMTGAAGMPVAVLNHNRVMGYMVPAELYEAMMERLEDLELSELAKSRLGEKGVPVSLDD
L

Download         Length: 246 bp

>AT199983 NZ_CP097675:c5358812-5358570 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F8G1E7

Antitoxin

Source ID Structure
AlphaFold DB F8G1E6

References