Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-RelB
Location 3252527..3253050 Replicon chromosome
Accession NZ_CP073638
Organism Burkholderia cepacia strain ZJ1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KEC55_RS31075 Protein ID WP_282508861.1
Coordinates 3252527..3252793 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KEC55_RS31080 Protein ID WP_282508862.1
Coordinates 3252790..3253050 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KEC55_RS31045 (KEC55_30990) 3247802..3248716 + 915 WP_282508855.1 LysR family transcriptional regulator -
KEC55_RS31050 (KEC55_30995) 3248773..3249372 + 600 WP_282508856.1 GNAT family protein -
KEC55_RS31055 (KEC55_31000) 3249475..3250053 - 579 WP_282508857.1 DUF4142 domain-containing protein -
KEC55_RS31060 (KEC55_31005) 3250447..3251070 - 624 WP_282508858.1 HAD hydrolase-like protein -
KEC55_RS31065 (KEC55_31010) 3251088..3251918 - 831 WP_282508859.1 substrate-binding domain-containing protein -
KEC55_RS31070 (KEC55_31015) 3252125..3252508 + 384 WP_282508860.1 DUF4087 domain-containing protein -
KEC55_RS31075 (KEC55_31020) 3252527..3252793 - 267 WP_282508861.1 Txe/YoeB family addiction module toxin Toxin
KEC55_RS31080 (KEC55_31025) 3252790..3253050 - 261 WP_282508862.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
KEC55_RS31085 (KEC55_31030) 3253275..3253718 + 444 WP_282508863.1 GNAT family N-acetyltransferase -
KEC55_RS31090 (KEC55_31035) 3253776..3253994 + 219 WP_006480837.1 DUF1653 domain-containing protein -
KEC55_RS31095 (KEC55_31040) 3254050..3255261 - 1212 WP_282508864.1 crosslink repair DNA glycosylase YcaQ family protein -
KEC55_RS31100 (KEC55_31045) 3255659..3257047 - 1389 WP_282508865.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10441.80 Da        Isoelectric Point: 9.4570

>T199979 WP_282508861.1 NZ_CP073638:c3252793-3252527 [Burkholderia cepacia]
MSVRRALLTSDAWDDYVYWQGQDRKTLKRINQLIRETQRTPFEGIGKPEPLKANLSGFWSRRIDDTNRLVYEADDLQISI
VSCRYRYG

Download         Length: 267 bp

>T199979 NZ_CP097675:4162362-4162580 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9791.03 Da        Isoelectric Point: 6.0717

>AT199979 WP_282508862.1 NZ_CP073638:c3253050-3252790 [Burkholderia cepacia]
MRTIHFSDARSNLKTVIDQVVDDADVTLITRRDSPNAVIMSQDYYDSLMETVHLLRSPANVAHLERSIAQLRKGKAKEHK
LAEDDE

Download         Length: 261 bp

>AT199979 NZ_CP097675:4161961-4162335 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References