Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3101164..3102384 Replicon chromosome
Accession NZ_CP073638
Organism Burkholderia cepacia strain ZJ1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KEC55_RS30395 Protein ID WP_282508748.1
Coordinates 3101164..3101745 (-) Length 194 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KEC55_RS30400 Protein ID WP_282508749.1
Coordinates 3101827..3102384 (-) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KEC55_RS30380 (KEC55_30315) 3096870..3098915 - 2046 WP_282508745.1 MacB family efflux pump subunit -
KEC55_RS30385 (KEC55_30320) 3098918..3100111 - 1194 WP_282508746.1 efflux RND transporter periplasmic adaptor subunit -
KEC55_RS30390 (KEC55_30325) 3100380..3101108 - 729 WP_282508747.1 class I SAM-dependent methyltransferase -
KEC55_RS30395 (KEC55_30330) 3101164..3101745 - 582 WP_282508748.1 HD domain-containing protein Toxin
KEC55_RS30400 (KEC55_30335) 3101827..3102384 - 558 WP_282508749.1 helix-turn-helix transcriptional regulator Antitoxin
KEC55_RS30405 (KEC55_30340) 3102469..3103107 - 639 WP_282508750.1 hypothetical protein -
KEC55_RS30410 (KEC55_30345) 3103448..3104845 + 1398 WP_282508751.1 DUF308 domain-containing protein -
KEC55_RS30415 (KEC55_30350) 3104939..3105517 + 579 WP_282508752.1 hypothetical protein -
KEC55_RS30420 (KEC55_30355) 3105783..3106514 + 732 WP_282508753.1 ribonuclease T2 -
KEC55_RS30425 (KEC55_30360) 3106634..3107269 - 636 WP_282508754.1 isochorismatase family cysteine hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-173)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-64)


Sequences

Toxin        


Download         Length: 194 a.a.        Molecular weight: 21474.01 Da        Isoelectric Point: 5.5158

>T199978 WP_282508748.1 NZ_CP073638:c3101745-3101164 [Burkholderia cepacia]
MNPDTIHARLDFLREAERLKDVLRSGHTSGGRPESTAEHSWRLCLMALVFADALPGVDTLKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSAHERDDLLTLTASLDRARRDEIVALWDEYEAAASPEARAAKALDKLETILQHNQGSNPPDFDYSFNLDY
GRRHTDAAPLFSAIRAIVDADTQRRIDANRQHA

Download         Length: 582 bp

>T199978 NZ_CP097675:c2744998-2743676 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCTGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20206.19 Da        Isoelectric Point: 10.6014

>AT199978 WP_282508749.1 NZ_CP073638:c3102384-3101827 [Burkholderia cepacia]
MTASPLHTPPLGPQLKRWRALHRVKQSHAAELFGVAQSTISRWEAGRQQMSPDERATAERLLAARLDSAGDHALARLIAG
SAGRMHLVCDLTHRLLACSPARTAEFSQPLSMLLGTSLWRFATPEIVRMEAALDPLGWHDRAGPPSVEFDTGANASRVVP
IRGSLCRWTRMTLSDGSAARLVETL

Download         Length: 558 bp

>AT199978 NZ_CP097675:c2745264-2744998 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References