Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2686833..2687398 Replicon chromosome
Accession NZ_CP073638
Organism Burkholderia cepacia strain ZJ1

Toxin (Protein)


Gene name vapC Uniprot ID A0A8E1S7L3
Locus tag KEC55_RS28575 Protein ID WP_060343311.1
Coordinates 2686833..2687204 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B1FGI9
Locus tag KEC55_RS28580 Protein ID WP_006752328.1
Coordinates 2687201..2687398 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KEC55_RS28560 (KEC55_28500) 2682690..2683415 + 726 WP_282508463.1 site-2 protease family protein -
KEC55_RS28565 (KEC55_28505) 2683481..2684860 - 1380 WP_282508464.1 MFS transporter -
KEC55_RS28570 (KEC55_28510) 2685109..2686686 + 1578 WP_282508465.1 aldehyde dehydrogenase (NADP(+)) -
KEC55_RS28575 (KEC55_28515) 2686833..2687204 - 372 WP_060343311.1 PIN domain-containing protein Toxin
KEC55_RS28580 (KEC55_28520) 2687201..2687398 - 198 WP_006752328.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
KEC55_RS28585 (KEC55_28525) 2687648..2688199 + 552 WP_282508466.1 hypothetical protein -
KEC55_RS28590 (KEC55_28530) 2688352..2689266 - 915 WP_282508467.1 5-dehydro-4-deoxyglucarate dehydratase -
KEC55_RS28595 (KEC55_28535) 2689497..2691050 + 1554 WP_282508468.1 galactarate dehydratase -
KEC55_RS28600 (KEC55_28540) 2691248..2691640 + 393 WP_282508469.1 nuclear transport factor 2 family protein -
KEC55_RS28605 (KEC55_28545) 2691720..2692175 + 456 WP_282508470.1 RbsD/FucU family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-112)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-46)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13384.42 Da        Isoelectric Point: 5.5223

>T199977 WP_060343311.1 NZ_CP073638:c2687204-2686833 [Burkholderia cepacia]
MILVDTSVWIDHLRAGDATLTTLLEAERVLIHPFVVGELALGSLRDRETVLDALRDLPAAAAATDDEVQRMIDVAPLYGL
GIGYVDAHLLASVRLTSGSKLWTRDRRLLAAAERLQLAAHPAH

Download         Length: 372 bp

>T199977 NZ_CP097675:2019259-2019361 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7054.10 Da        Isoelectric Point: 10.6826

>AT199977 WP_006752328.1 NZ_CP073638:c2687398-2687201 [Burkholderia cepacia]
MRTTLSLDDALLAKAQQLTGVTEKSALVREALRALIARESARRLARLGGTEPDLESVPRRPSEPA

Download         Length: 198 bp

>AT199977 NZ_CP097675:c2019368-2019223 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2S9KMB8

References