Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1548542..1549162 Replicon chromosome
Accession NZ_CP073638
Organism Burkholderia cepacia strain ZJ1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KEC55_RS23205 Protein ID WP_282511191.1
Coordinates 1548542..1548859 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KEC55_RS23210 Protein ID WP_124446336.1
Coordinates 1548863..1549162 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KEC55_RS23195 (KEC55_23145) 1545080..1546513 - 1434 WP_282511188.1 aldehyde dehydrogenase family protein -
KEC55_RS23200 (KEC55_23150) 1546543..1548183 - 1641 WP_176046073.1 acetolactate synthase large subunit -
KEC55_RS23205 (KEC55_23155) 1548542..1548859 + 318 WP_282511191.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KEC55_RS23210 (KEC55_23160) 1548863..1549162 + 300 WP_124446336.1 putative addiction module antidote protein Antitoxin
KEC55_RS23215 (KEC55_23165) 1549211..1550497 - 1287 WP_282511194.1 DUF445 domain-containing protein -
KEC55_RS23220 (KEC55_23170) 1550605..1551823 - 1219 Protein_1334 anthranilate 1,2-dioxygenase system ferredoxin--NAD(+) reductase -
KEC55_RS23225 (KEC55_23175) 1551813..1552139 - 327 WP_282511195.1 anthranilate 1,2-dioxygenase ferredoxin subunit AndAb -
KEC55_RS23230 (KEC55_23180) 1552157..1552633 - 477 WP_166954302.1 anthranilate 1,2-dioxygenase small subunit AndAd -
KEC55_RS23235 (KEC55_23185) 1552648..1553919 - 1272 WP_282511201.1 anthranilate 1,2-dioxygenase large subunit AndAc -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(9-100)

Antitoxin

Uncharacterized protein HI1420

(6-93)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11817.59 Da        Isoelectric Point: 9.9432

>T199974 WP_282511191.1 NZ_CP073638:1548542-1548859 [Burkholderia cepacia]
MPYSAPTFSIRTTDVFDAWFAGLQDRVAKRRIQARIDRLSMGNPGDWKSAGAPVVEMRIDHGPGYRVYYVRRGPIWVILL
CGGNKSTQQADIRAAHAMLAHLDME

Download         Length: 318 bp

>T199974 NZ_CP097675:356313-356660 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10663.04 Da        Isoelectric Point: 6.3224

>AT199974 WP_124446336.1 NZ_CP073638:1548863-1549162 [Burkholderia cepacia]
MDKISTRPWDSAEHLKTEDDMADYFEACLQEAGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGSKAHA

Download         Length: 300 bp

>AT199974 NZ_CP097675:356660-356959 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References