Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 532884..533523 Replicon chromosome
Accession NZ_CP073638
Organism Burkholderia cepacia strain ZJ1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KEC55_RS18835 Protein ID WP_176045540.1
Coordinates 533107..533523 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KEC55_RS18830 Protein ID WP_282509534.1
Coordinates 532884..533120 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KEC55_RS18810 (KEC55_18770) 528644..530230 + 1587 WP_282509526.1 FadD3 family acyl-CoA ligase -
KEC55_RS18815 (KEC55_18775) 530263..531036 + 774 WP_282509528.1 SDR family oxidoreductase -
KEC55_RS18820 (KEC55_18780) 531115..531498 - 384 WP_282509530.1 hypothetical protein -
KEC55_RS18825 (KEC55_18785) 531829..532488 + 660 WP_282509532.1 hypothetical protein -
KEC55_RS18830 (KEC55_18790) 532884..533120 + 237 WP_282509534.1 DNA-binding protein Antitoxin
KEC55_RS18835 (KEC55_18795) 533107..533523 + 417 WP_176045540.1 type II toxin-antitoxin system VapC family toxin Toxin
KEC55_RS18840 (KEC55_18800) 533723..534619 + 897 WP_124577104.1 VOC family protein -
KEC55_RS18845 (KEC55_18805) 534629..535522 + 894 WP_282509540.1 CoA-transferase -
KEC55_RS18850 (KEC55_18810) 535533..536330 + 798 WP_282509541.1 ketoacid CoA transferase -
KEC55_RS18855 (KEC55_18815) 536339..537259 + 921 WP_282509543.1 enoyl-CoA hydratase -
KEC55_RS18860 (KEC55_18820) 537256..538356 + 1101 WP_282509545.1 nitronate monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15296.60 Da        Isoelectric Point: 8.5855

>T199972 WP_176045540.1 NZ_CP073638:533107-533523 [Burkholderia cepacia]
VYLIDTNVISEIRKGKRTNRGVRAFFRQAAADASPLYLSVVTVAELRRGVDLIRHRGDHPQASALEAWMATILAGYAPNI
LPVDIEVSQMWGHLRVPDPTHELDKLIAATALINDLTVVTRNVADFARTGVRLLNPFD

Download         Length: 417 bp

>T199972 NZ_CP097674:c19433-19017 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8626.66 Da        Isoelectric Point: 5.0774

>AT199972 WP_282509534.1 NZ_CP073638:532884-533120 [Burkholderia cepacia]
MANLLVRNVDDSIVQSLREQAAANGRSAEAEHRAILADALGRPKRKTFAQVLMSMPEVGEDADFQRVQDSGEARRVFD

Download         Length: 237 bp

>AT199972 NZ_CP097674:c19660-19430 [Klebsiella pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References