Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 266671..268436 Replicon chromosome
Accession NZ_CP073638
Organism Burkholderia cepacia strain ZJ1

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag KEC55_RS17725 Protein ID WP_282509089.1
Coordinates 266671..267582 (+) Length 304 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag KEC55_RS17730 Protein ID WP_282509091.1
Coordinates 267579..268436 (+) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KEC55_RS17695 (KEC55_17655) 262047..263126 - 1080 WP_282509078.1 porin -
KEC55_RS17700 (KEC55_17660) 263573..263890 + 318 WP_006489883.1 non-heme iron oxygenase ferredoxin subunit -
KEC55_RS17705 (KEC55_17665) 263892..264203 + 312 WP_027789383.1 hypothetical protein -
KEC55_RS17710 (KEC55_17670) 264258..265328 + 1071 WP_282509083.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
KEC55_RS17715 (KEC55_17675) 265321..266091 + 771 WP_282509085.1 SDR family oxidoreductase -
KEC55_RS17720 (KEC55_17680) 266125..266652 + 528 WP_039344094.1 cupin domain-containing protein -
KEC55_RS17725 (KEC55_17685) 266671..267582 + 912 WP_282509089.1 alpha/beta fold hydrolase Toxin
KEC55_RS17730 (KEC55_17690) 267579..268436 + 858 WP_282509091.1 IclR family transcriptional regulator Antitoxin
KEC55_RS17735 (KEC55_17695) 268433..269230 + 798 WP_282509093.1 SDR family oxidoreductase -
KEC55_RS17740 (KEC55_17700) 269223..270890 + 1668 WP_282509095.1 thiamine pyrophosphate-binding protein -
KEC55_RS17745 (KEC55_17705) 270883..271698 + 816 WP_282509097.1 aspartate dehydrogenase -
KEC55_RS17750 (KEC55_17710) 271771..273261 + 1491 WP_282509102.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(56-284)

Antitoxin

Transcription regulator IclR, C-terminal

(143-266)


Sequences

Toxin        


Download         Length: 304 a.a.        Molecular weight: 30997.22 Da        Isoelectric Point: 7.4246

>T199971 WP_282509089.1 NZ_CP073638:266671-267582 [Burkholderia cepacia]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAGEAGAQHAGRALPVVLLHGIGSGAASWVHQLDTLGASR
RVLAWDAPGYGVSTPVHGASPAAADYAASLNAWLEALGIDRCVLVGHSLGAIIAGGLARVMPARIAGLLLVSPAGGYGSA
PAETRESRRDARLAMLAELGPAGLAEQRSGNMLSGFANEEAKAWVRWNMARIVPAGYAQATHLLANADLATDLAGFRGRT
AVAVGANDAITPPAACERIAAAAHVALQVIPQAGHAGYVEAPAVYSALIDGFCRQCDQQRGLA

Download         Length: 912 bp

>T199971 NZ_CP097673:215680-215829 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31436.91 Da        Isoelectric Point: 6.3590

>AT199971 WP_282509091.1 NZ_CP073638:267579-268436 [Burkholderia cepacia]
MSEPLQQPESENTKSDANYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQSPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELQALYPEGALNRMTSATPETIDALYEMIREDALRGYGVSNSSFERGISVVTAPVRNETQRIVACITVTVP
RPEIDAGLIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 858 bp

>AT199971 NZ_CP097673:c215635-215576 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References