Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 56288..56943 Replicon chromosome
Accession NZ_CP073638
Organism Burkholderia cepacia strain ZJ1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KEC55_RS16805 Protein ID WP_282508916.1
Coordinates 56524..56943 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KEC55_RS16800 Protein ID WP_059619278.1
Coordinates 56288..56527 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KEC55_RS16775 (KEC55_16735) 51558..51953 - 396 WP_176049919.1 type II toxin-antitoxin system VapC family toxin -
KEC55_RS16780 (KEC55_16740) 51950..52189 - 240 WP_011659184.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
KEC55_RS16785 (KEC55_16745) 52281..52964 - 684 WP_282508913.1 Fe2+-dependent dioxygenase -
KEC55_RS16790 (KEC55_16750) 52961..53728 - 768 WP_282508914.1 tetratricopeptide repeat protein -
KEC55_RS16795 (KEC55_16755) 53732..55978 - 2247 WP_282508915.1 TonB-dependent siderophore receptor -
KEC55_RS16800 (KEC55_16760) 56288..56527 + 240 WP_059619278.1 Arc family DNA-binding protein Antitoxin
KEC55_RS16805 (KEC55_16765) 56524..56943 + 420 WP_282508916.1 PIN domain-containing protein Toxin
KEC55_RS16810 (KEC55_16770) 57080..58375 - 1296 WP_282508917.1 aspartate carbamoyltransferase -
KEC55_RS16815 (KEC55_16775) 58610..58744 + 135 WP_009688930.1 entericidin A/B family lipoprotein -
KEC55_RS16820 (KEC55_16780) 58840..59388 - 549 WP_282508918.1 permease -
KEC55_RS16825 (KEC55_16785) 59573..60514 - 942 WP_282508919.1 DMT family transporter -
KEC55_RS16830 (KEC55_16790) 60689..61483 - 795 WP_282508920.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(7-46)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15163.47 Da        Isoelectric Point: 5.9052

>T199970 WP_282508916.1 NZ_CP073638:56524-56943 [Burkholderia cepacia]
MILVDTNVISEPLRREPSAAVIEWLDAQNVETLFLAATSLAEMRLGVAVLPEGRRREWLHQSIEQRVLPLFRGRILPFDD
AASKAYASLRARARAAGAAIAPSDGFIAGTAEANGLIVATRDVTPFEAMGIRVIDPWAR

Download         Length: 420 bp

>T199970 NZ_CP097673:150667-151110 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAACAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
TGGGCACGCTATCGCGGCCGGCGCCGTCCTAGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGAAAGCCGCTCTCTGCAGGGTAATTTCTTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8639.83 Da        Isoelectric Point: 5.6643

>AT199970 WP_059619278.1 NZ_CP073638:56288-56527 [Burkholderia cepacia]
MPVITVRNLPDEVHRALRIRAAQHGRSTEAEVRDILEQAVLPGGRLKLGTMLAAIGQEAGGFDFDAQRDKTPADPMSFE

Download         Length: 240 bp

>AT199970 NZ_CP097673:150440-150670 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGCTCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References