Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1903617..1904278 Replicon chromosome
Accession NZ_CP073637
Organism Burkholderia cepacia strain ZJ1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KEC55_RS08825 Protein ID WP_282505042.1
Coordinates 1903982..1904278 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KEC55_RS08820 Protein ID WP_282505040.1
Coordinates 1903617..1903979 (-) Length 121 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KEC55_RS08800 (KEC55_08755) 1899389..1900234 + 846 WP_282505037.1 carbon-nitrogen hydrolase family protein -
KEC55_RS08805 (KEC55_08760) 1900359..1901699 + 1341 WP_282505038.1 APC family permease -
KEC55_RS08810 (KEC55_08765) 1901944..1902813 + 870 WP_262530411.1 LD-carboxypeptidase -
KEC55_RS08815 (KEC55_08770) 1902831..1903084 - 254 Protein_1715 helix-turn-helix domain-containing protein -
KEC55_RS08820 (KEC55_08775) 1903617..1903979 - 363 WP_282505040.1 putative addiction module antidote protein Antitoxin
KEC55_RS08825 (KEC55_08780) 1903982..1904278 - 297 WP_282505042.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KEC55_RS08830 (KEC55_08785) 1904767..1907940 - 3174 WP_282507508.1 multidrug efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-95)

Antitoxin

Uncharacterized protein HI1420

(16-95)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10761.47 Da        Isoelectric Point: 9.9712

>T199969 WP_282505042.1 NZ_CP073637:c1904278-1903982 [Burkholderia cepacia]
MFKVLTTPQFDNWLDGLRDPVGSAAISLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRRGKIIVVVLCGGDKS
TQKKDIKAAKQIAGELED

Download         Length: 297 bp

>T199969 NZ_CP097673:14149-14631 [Klebsiella pneumoniae]
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCACTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGAAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCTACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGTGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGCGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 12755.58 Da        Isoelectric Point: 9.5609

>AT199969 WP_282505040.1 NZ_CP073637:c1903979-1903617 [Burkholderia cepacia]
MKISELAEFDGSKYLKDEEAIRHYLAQAFEDGDPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPTVQAAEAAPVPAPTRSRPRARAAAHT

Download         Length: 363 bp

>AT199969 NZ_CP097673:13895-14161 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGTACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGATTCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References