Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1812548..1813224 Replicon chromosome
Accession NZ_CP073637
Organism Burkholderia cepacia strain ZJ1

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag KEC55_RS08355 Protein ID WP_282504929.1
Coordinates 1812808..1813224 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag KEC55_RS08350 Protein ID WP_282504928.1
Coordinates 1812548..1812811 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KEC55_RS08335 (KEC55_08300) 1808086..1810341 + 2256 Protein_1619 TonB-dependent siderophore receptor -
KEC55_RS08340 (KEC55_08305) 1810442..1811281 + 840 WP_282504926.1 N(5)-hydroxyornithine transformylase PvdF -
KEC55_RS08345 (KEC55_08310) 1811281..1812297 + 1017 WP_282504927.1 GNAT family N-acetyltransferase -
KEC55_RS08350 (KEC55_08315) 1812548..1812811 + 264 WP_282504928.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
KEC55_RS08355 (KEC55_08320) 1812808..1813224 + 417 WP_282504929.1 PIN domain-containing protein Toxin
KEC55_RS08360 (KEC55_08325) 1813273..1814178 - 906 WP_282504930.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
KEC55_RS08365 (KEC55_08330) 1814147..1815220 - 1074 WP_282507503.1 type IV toxin-antitoxin system AbiEi family antitoxin -
KEC55_RS08370 (KEC55_08335) 1815559..1816722 + 1164 WP_282504931.1 M20 aminoacylase family protein -
KEC55_RS08375 (KEC55_08340) 1816894..1817433 + 540 WP_048244354.1 outer membrane protein assembly factor BamE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-130)

Antitoxin

SpoVT-AbrB domain

(7-54)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14566.75 Da        Isoelectric Point: 7.8895

>T199968 WP_282504929.1 NZ_CP073637:1812808-1813224 [Burkholderia cepacia]
VTTLYMLDTNICSFIMRERPPVVLSRLQSCVNAQHRIVVSAITYAEMRFGAVGRKASPKHAELVMAFVSRLDGVLSWDTA
AVDATAAIRADLAARGTPIGANDASIAGHAIAAGAVLVTNNGREFGRVAGLSLEDWAA

Download         Length: 417 bp

>T199968 NZ_CP097671:c8756-8442 [Klebsiella pneumoniae]
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGCGATTTACAACGCCTTCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGGAGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CGTTTCTGCCGCTGGAATATAAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCAGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9691.92 Da        Isoelectric Point: 4.4819

>AT199968 WP_282504928.1 NZ_CP073637:1812548-1812811 [Burkholderia cepacia]
MRTVSIFKNARNQAIRIPKDMEFEGVTELEIRREGDTLLLRPVRPTWISFASEPLADADFLAERPAVIESGRFDLSGEDA
APTGSSQ

Download         Length: 264 bp

>AT199968 NZ_CP097671:c9022-8744 [Klebsiella pneumoniae]
ATGTCATCAGCAACATCCATCAGGCTCGATGAAGAACTTAAGGACCGGCTGAAAACGCTGGCCGATGACCGGCACCGCTC
AGCGCACGCGCTAATGCTGGAGGCAATCACCGAATACATCGACCGGGAAGAGAAGCGCAGCCAGTACCTGCGGGACGGAC
AGGCCGCATGGCAGCACTATCAGGAAACGGGTCTGCACCTTACTGCGGAAGAAGCGGAAGCCTGGATAAGTACCTGGGGA
ACTGAGAACGAGCAGGATGCTCCGCCATGCCACAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References