Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 1858489..1859024 Replicon chromosome
Accession NZ_CP073633
Organism Methylorubrum extorquens strain ATCC 55366

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag KEC54_RS08890 Protein ID WP_283536038.1
Coordinates 1858734..1859024 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag KEC54_RS08885 Protein ID WP_056111912.1
Coordinates 1858489..1858737 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KEC54_RS08870 (KEC54_08740) 1853695..1855290 - 1596 WP_056155717.1 DUF5691 domain-containing protein -
KEC54_RS08875 (KEC54_08745) 1855290..1856657 - 1368 WP_056111918.1 SWIM zinc finger family protein -
KEC54_RS08880 (KEC54_08750) 1856853..1858355 - 1503 WP_056111915.1 glucose-6-phosphate dehydrogenase -
KEC54_RS08885 (KEC54_08755) 1858489..1858737 + 249 WP_056111912.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
KEC54_RS08890 (KEC54_08760) 1858734..1859024 + 291 WP_283536038.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KEC54_RS08895 (KEC54_08765) 1859082..1859753 + 672 WP_283536039.1 uracil-DNA glycosylase family protein -
KEC54_RS08900 (KEC54_08770) 1859761..1861287 - 1527 WP_056155707.1 alginate export family protein -
KEC54_RS08905 (KEC54_08775) 1861612..1862310 + 699 WP_056111903.1 orotidine-5'-phosphate decarboxylase -
KEC54_RS08910 (KEC54_08780) 1862313..1862657 + 345 WP_056111900.1 DUF1330 domain-containing protein -
KEC54_RS08915 (KEC54_08785) 1862677..1863300 - 624 WP_012253132.1 TetR/AcrR family transcriptional regulator -
KEC54_RS08920 (KEC54_08790) 1863523..1863723 - 201 WP_003605412.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-92)

Antitoxin

Antitoxin ParD

(4-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10864.38 Da        Isoelectric Point: 10.3918

>T199963 WP_283536038.1 NZ_CP073633:1858734-1859024 [Methylorubrum extorquens]
MSVRLSPSARADLSRIWDDSAERWGADQADRYIRLLAGGFDRLAEDPARGLRAAEIRKGYFRLSVGSHVLFDRLGAEGGI
EVIRILHGRMDFKRHL

Download         Length: 291 bp

>T199963 NZ_CP097670:4176752-4176970 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8934.93 Da        Isoelectric Point: 4.3813

>AT199963 WP_056111912.1 NZ_CP073633:1858489-1858737 [Methylorubrum extorquens]
MPRNTSVSLGEHFAQFIDRQVEGGRYGSASEVVRAGLRLLEEQEAALDTLRAALIEGEESGPPEPFDTETFLREKRAGAI
CG

Download         Length: 249 bp

>AT199963 NZ_CP097670:4176351-4176725 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References