199962

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 884834..885557 Replicon chromosome
Accession NZ_CP073633
Organism Methylorubrum extorquens strain ATCC 55366

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag KEC54_RS04290 Protein ID WP_082490329.1
Coordinates 885177..885557 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag KEC54_RS04285 Protein ID WP_012252566.1
Coordinates 884834..885172 (-) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KEC54_RS04255 (KEC54_04175) 880034..882295 + 2262 WP_056120147.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
KEC54_RS04260 (KEC54_04180) 882617..882940 + 324 WP_012252561.1 CrcB family protein -
KEC54_RS04265 (KEC54_04185) 882951..883388 + 438 WP_283535904.1 EamA family transporter -
KEC54_RS04270 (KEC54_04190) 883376..884050 + 675 WP_283535905.1 M15 family metallopeptidase -
KEC54_RS04275 (KEC54_04195) 884219..884506 + 288 WP_056120150.1 hypothetical protein -
KEC54_RS04280 (KEC54_04200) 884503..884829 + 327 WP_056120153.1 hypothetical protein -
KEC54_RS04285 (KEC54_04205) 884834..885172 - 339 WP_012252566.1 helix-turn-helix transcriptional regulator Antitoxin
KEC54_RS04290 (KEC54_04210) 885177..885557 - 381 WP_082490329.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KEC54_RS04295 (KEC54_04215) 885673..886314 - 642 WP_056120158.1 MarR family winged helix-turn-helix transcriptional regulator -
KEC54_RS04300 (KEC54_04220) 886561..888738 + 2178 WP_056120162.1 glycosyltransferase -
KEC54_RS04305 (KEC54_04225) 888770..889537 + 768 WP_056120166.1 glucose-1-phosphate cytidylyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(19-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-90)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14072.11 Da        Isoelectric Point: 8.7347

>T199962 WP_082490329.1 NZ_CP073633:c885557-885177 [Methylorubrum extorquens]
VTPASPPLRECWFVGSSRKDLSAFPDVVRSEFGHALHEAQCGLEPYAAKALKGFGGRGVLEIIENHDGDTFRAVYTVRFA
GAIYVLHCFQKKSKKGIATPQHDIELIRARLRDAETLHRIKIEEGR

Download         Length: 381 bp

>T199962 NZ_CP097670:c2762362-2761040 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCTGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 12221.05 Da        Isoelectric Point: 7.3219

>AT199962 WP_012252566.1 NZ_CP073633:c885172-884834 [Methylorubrum extorquens]
MTHPEPEAWRSSGNVFADLELPDAQELHLKSSLVIELRRQIEGRKLTQTAAATILGIGQADLSKLLRGGLRGTSVERLMR
MLTAFDQDVEITVRPHPKAGEGGRITVTPVPA

Download         Length: 339 bp

>AT199962 NZ_CP097670:c2762628-2762362 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References