Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1000648..1001134 Replicon chromosome
Accession NZ_CP073632
Organism Streptococcus parasuis strain NN1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KEM15_RS05160 Protein ID WP_217375106.1
Coordinates 1000648..1000905 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KEM15_RS05165 Protein ID WP_105142535.1
Coordinates 1000895..1001134 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KEM15_RS05130 (KEM15_05040) 996022..996720 + 699 WP_254451660.1 DUF3307 domain-containing protein -
KEM15_RS05135 (KEM15_05050) 996990..997157 + 168 Protein_975 IS630 family transposase -
KEM15_RS05140 (KEM15_05055) 997303..998372 + 1070 Protein_976 tyrosine recombinase XerS -
KEM15_RS05145 (KEM15_05060) 998504..998728 + 225 WP_217469409.1 hypothetical protein -
KEM15_RS05150 (KEM15_05065) 999004..999945 - 942 WP_217375105.1 sensor histidine kinase -
KEM15_RS05155 (KEM15_05070) 999942..1000610 - 669 WP_172036118.1 response regulator transcription factor -
KEM15_RS05160 (KEM15_05075) 1000648..1000905 - 258 WP_217375106.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KEM15_RS05165 (KEM15_05080) 1000895..1001134 - 240 WP_105142535.1 DUF6290 family protein Antitoxin
KEM15_RS05170 (KEM15_05085) 1001225..1003195 - 1971 WP_274503790.1 ABC transporter permease -
KEM15_RS05175 (KEM15_05090) 1003196..1003948 - 753 WP_174845939.1 ABC transporter ATP-binding protein -
KEM15_RS05180 (KEM15_05095) 1003957..1004346 - 390 WP_274503791.1 NisI/SpaI family lantibiotic immunity lipoprotein -
KEM15_RS05185 (KEM15_05100) 1004638..1005802 - 1165 Protein_985 ATP-grasp domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 972704..1023181 50477


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-75)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9913.64 Da        Isoelectric Point: 10.6957

>T199961 WP_217375106.1 NZ_CP073632:c1000905-1000648 [Streptococcus parasuis]
MSYKVILSARVQKQIRKMDKTAASLILRYLYKHIDGCDNPRQYGIALTANRSGQWRYRIGNYRVIVSIEDDKLIMTSIKM
RNGSM

Download         Length: 258 bp

>T199961 NZ_CP097670:2029933-2030035 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8763.02 Da        Isoelectric Point: 3.8548

>AT199961 WP_105142535.1 NZ_CP073632:c1001134-1000895 [Streptococcus parasuis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLAALEDEYDARVADIAWAEYQADLANGIEPITLEQMAEELGIEL

Download         Length: 240 bp

>AT199961 NZ_CP097670:c2030042-2029897 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References