Detailed information of TA system TA199961

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1000648..1001134
• Replicon: chromosome
• Accession: NZ_CP073632
• Organism: Streptococcus parasuis strain NN1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KEM15_RS05160
• Protein ID: WP_217375106.1
• Coordinates: 1000648..1000905 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: KEM15_RS05165
• Protein ID: WP_105142535.1
• Coordinates: 1000895..1001134 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KEM15_RS05130 (KEM15_05040)	996022..996720	+	699	WP_254451660.1	DUF3307 domain-containing protein	-
KEM15_RS05135 (KEM15_05050)	996990..997157	+	168	Protein_975	IS630 family transposase	-
KEM15_RS05140 (KEM15_05055)	997303..998372	+	1070	Protein_976	tyrosine recombinase XerS	-
KEM15_RS05145 (KEM15_05060)	998504..998728	+	225	WP_217469409.1	hypothetical protein	-
KEM15_RS05150 (KEM15_05065)	999004..999945	-	942	WP_217375105.1	sensor histidine kinase	-
KEM15_RS05155 (KEM15_05070)	999942..1000610	-	669	WP_172036118.1	response regulator transcription factor	-
KEM15_RS05160 (KEM15_05075)	1000648..1000905	-	258	WP_217375106.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KEM15_RS05165 (KEM15_05080)	1000895..1001134	-	240	WP_105142535.1	DUF6290 family protein	Antitoxin
KEM15_RS05170 (KEM15_05085)	1001225..1003195	-	1971	WP_274503790.1	ABC transporter permease	-
KEM15_RS05175 (KEM15_05090)	1003196..1003948	-	753	WP_174845939.1	ABC transporter ATP-binding protein	-
KEM15_RS05180 (KEM15_05095)	1003957..1004346	-	390	WP_274503791.1	NisI/SpaI family lantibiotic immunity lipoprotein	-
KEM15_RS05185 (KEM15_05100)	1004638..1005802	-	1165	Protein_985	ATP-grasp domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	972704..1023181	50477

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-75)

Antitoxin

• Protein of unknown function DUF6290 (1-75)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9913.64 Da
• Isoelectric Point: 10.6957

>T199961 WP_217375106.1 NZ_CP073632:c1000905-1000648 [Streptococcus parasuis]
MSYKVILSARVQKQIRKMDKTAASLILRYLYKHIDGCDNPRQYGIALTANRSGQWRYRIGNYRVIVSIEDDKLIMTSIKM
RNGSM

Nucleotide

• Length: 258 bp

>T199961 NZ_CP097670:2029933-2030035 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8763.02 Da
• Isoelectric Point: 3.8548

>AT199961 WP_105142535.1 NZ_CP073632:c1001134-1000895 [Streptococcus parasuis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLAALEDEYDARVADIAWAEYQADLANGIEPITLEQMAEELGIEL

Nucleotide

• Length: 240 bp

>AT199961 NZ_CP097670:c2030042-2029897 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT