Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 22377..22858 Replicon chromosome
Accession NZ_CP073631
Organism Clostridium sp. C1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KEC48_RS00115 Protein ID WP_087357194.1
Coordinates 22592..22858 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KEC48_RS00110 Protein ID WP_087357195.1
Coordinates 22377..22595 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KEC48_RS00085 (KEC48_00085) 17847..18197 + 351 WP_087357200.1 hypothetical protein -
KEC48_RS00090 (KEC48_00090) 18207..19373 + 1167 WP_087357199.1 cation diffusion facilitator family transporter -
KEC48_RS00095 (KEC48_00095) 19679..20698 + 1020 WP_211963627.1 ATP-binding cassette domain-containing protein -
KEC48_RS00100 (KEC48_00100) 20700..21365 + 666 WP_211963629.1 methionine ABC transporter permease -
KEC48_RS00105 (KEC48_00105) 21378..22190 + 813 WP_211963631.1 MetQ/NlpA family ABC transporter substrate-binding protein -
KEC48_RS00110 (KEC48_00110) 22377..22595 + 219 WP_087357195.1 DUF6290 family protein Antitoxin
KEC48_RS00115 (KEC48_00115) 22592..22858 + 267 WP_087357194.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KEC48_RS00120 (KEC48_00120) 23566..23772 + 207 WP_087357193.1 hypothetical protein -
KEC48_RS00125 (KEC48_00125) 24544..24861 + 318 WP_211963633.1 transcriptional regulator -
KEC48_RS00130 (KEC48_00130) 24964..26754 - 1791 WP_211963635.1 flavin reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-87)

Antitoxin

Protein of unknown function DUF6290

(1-70)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10553.49 Da        Isoelectric Point: 10.4974

>T199960 WP_087357194.1 NZ_CP073631:22592-22858 [Clostridium sp. C1]
MSYKVEYSKAAQKQIKKMDRYTQVMIMRWITKNLVGCTDPRVHGKGLKGNLKNQWRYRVGHYRILCDIEDDKLIILVINV
GHRREIYK

Download         Length: 267 bp

>T199960 NZ_CP097670:875868-876275 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8406.50 Da        Isoelectric Point: 4.3914

>AT199960 WP_087357195.1 NZ_CP073631:22377-22595 [Clostridium sp. C1]
MSFSIRLNAEEEKLFKNYANFHGISLSEAMKTALLEKIEEEYDIVIAQQAHEEYLKDPETISHENFMKELGL

Download         Length: 219 bp

>AT199960 NZ_CP097670:875621-875887 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References