Detailed information of TA system TA199959

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/GNAT-DUF1778
• Location: 2232327..2233072
• Replicon: chromosome
• Accession: NZ_CP073630
• Organism: Proteus terrae subsp. cibarius strain S24-2-1

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: KEF19_RS10290
• Protein ID: WP_211838030.1
• Coordinates: 2232327..2232818 (-)
• Length: 164 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: -
• Locus tag: KEF19_RS10295
• Protein ID: WP_075673024.1
• Coordinates: 2232806..2233072 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KEF19_RS10270	2227418..2228524	+	1107	WP_075673029.1	flagellar basal body P-ring protein FlgI	-
KEF19_RS10275	2228524..2229510	+	987	WP_109418912.1	flagellar assembly peptidoglycan hydrolase FlgJ	-
KEF19_RS10280	2229629..2231272	+	1644	WP_075673027.1	flagellar hook-associated protein FlgK	-
KEF19_RS10285	2231297..2232241	+	945	WP_087802138.1	flagellar hook-associated protein FlgL	-
KEF19_RS10290	2232327..2232818	-	492	WP_211838030.1	GNAT family N-acetyltransferase	Toxin
KEF19_RS10295	2232806..2233072	-	267	WP_075673024.1	DUF1778 domain-containing protein	Antitoxin
KEF19_RS10300	2233196..2233978	-	783	WP_075673023.1	flagellar biosynthetic protein FliR	-
KEF19_RS10305	2233984..2234253	-	270	WP_069367481.1	flagellar biosynthesis protein FliQ	-
KEF19_RS10310	2234269..2235039	-	771	WP_023581828.1	flagellar type III secretion system pore protein FliP	-
KEF19_RS10315	2235039..2235485	-	447	WP_075673022.1	flagellar biosynthetic protein FliO	-
KEF19_RS10320	2235489..2235899	-	411	WP_006533153.1	flagellar motor switch protein FliN	-
KEF19_RS10325	2235892..2236923	-	1032	WP_023581831.1	flagellar motor switch protein FliM	-
KEF19_RS10330	2236929..2237411	-	483	WP_006533151.1	flagellar basal body-associated protein FliL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (22-150)

Antitoxin

• Vibrio phage ICP1, Orf50 (2-87)

Sequences

Toxin

Protein

• Length: 164 a.a.
• Molecular weight: 18202.12 Da
• Isoelectric Point: 10.3965

>T199959 WP_211838030.1 NZ_CP073630:c2232818-2232327 [Proteus terrae subsp. cibarius]
MGKVTAPEPLSNSHEVADFYSSENVLDNWIKQRGLKNQFLGASRTFVVCEKNKKRVVGHYSLATGSVNHTEAMSHIRRNM
PDPIPVIILARLAVDKTFHGKGLGADLLRDAVLRCHHVAENIGVRAIMVHALTENAKHFYLHHGFKASSTQDKILFLALK
KKI

Nucleotide

• Length: 492 bp

>T199959 NZ_CP097670:741606-742091 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10111.62 Da
• Isoelectric Point: 4.5256

>AT199959 WP_075673024.1 NZ_CP073630:c2233072-2232806 [Proteus terrae subsp. cibarius]
MKADVQLNIRAKESQRALIDTAAEILHKSRTDFILETACQAAEDVILDRRTFNLNDAQYAEFIEIIDAPVDIDPALEKLL
MRKPLWEK

Nucleotide

• Length: 267 bp

>AT199959 NZ_CP097670:741316-741609 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA