Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 1199618..1201340 | Replicon | chromosome |
| Accession | NZ_CP073630 | ||
| Organism | Proteus terrae subsp. cibarius strain S24-2-1 | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | A0A1L5JQJ1 |
| Locus tag | KEF19_RS05520 | Protein ID | WP_000356586.1 |
| Coordinates | 1200402..1201340 (+) | Length | 313 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | A0A0M0HVB9 |
| Locus tag | KEF19_RS05515 | Protein ID | WP_002026815.1 |
| Coordinates | 1199618..1200409 (+) | Length | 264 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KEF19_RS05485 | 1195292..1195573 | + | 282 | WP_000433889.1 | type IV conjugative transfer system protein TraL | - |
| KEF19_RS05490 | 1195570..1196196 | + | 627 | WP_000667167.1 | TraE/TraK family type IV conjugative transfer system protein | - |
| KEF19_RS05495 | 1196180..1197079 | + | 900 | WP_001901416.1 | type-F conjugative transfer system secretin TraK | - |
| KEF19_RS05500 | 1197079..1198368 | + | 1290 | WP_000647307.1 | TraB/VirB10 family protein | - |
| KEF19_RS05505 | 1198443..1199015 | + | 573 | WP_001901415.1 | type IV conjugative transfer system lipoprotein TraV | - |
| KEF19_RS05510 | 1199012..1199398 | + | 387 | WP_000180225.1 | TraA family conjugative transfer protein | - |
| KEF19_RS05515 | 1199618..1200409 | + | 792 | WP_002026815.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| KEF19_RS05520 | 1200402..1201340 | + | 939 | WP_000356586.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| KEF19_RS05525 | 1201905..1204634 | + | 2730 | WP_001901413.1 | DEAD/DEAH box helicase | - |
| KEF19_RS05530 | 1204631..1205740 | + | 1110 | WP_000076135.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | floR / aph(6)-Id / aph(3'')-Ib / sul2 / dfrA1 | - | 1144395..1251482 | 107087 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 313 a.a. Molecular weight: 35482.75 Da Isoelectric Point: 5.0041
>T199958 WP_000356586.1 NZ_CP073630:1200402-1201340 [Proteus terrae subsp. cibarius]
MDKDSPYYKQVSLLIRMLPVVATERVFALKGGTAINLFVRDIPRLSVDIDLAYLPLEPRDEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSPVATIKIEVSPVARGTLHSAEIMPVQESVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGISREILVGFLTYTLSHPRPINEVMSPNWQPLDEKFQAEFDGMTFEKVECEDLASVRPIMLTALQK
HFTERDHAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE
MDKDSPYYKQVSLLIRMLPVVATERVFALKGGTAINLFVRDIPRLSVDIDLAYLPLEPRDEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSPVATIKIEVSPVARGTLHSAEIMPVQESVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGISREILVGFLTYTLSHPRPINEVMSPNWQPLDEKFQAEFDGMTFEKVECEDLASVRPIMLTALQK
HFTERDHAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE
Download Length: 939 bp
>T199958 NZ_CP097670:354089-354436 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA
Antitoxin
Download Length: 264 a.a. Molecular weight: 30116.50 Da Isoelectric Point: 9.1901
>AT199958 WP_002026815.1 NZ_CP073630:1199618-1200409 [Proteus terrae subsp. cibarius]
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLCSGVYYRPDAQGDIKPTWVDAIQALDVQLGVSVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRIDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLCSGVYYRPDAQGDIKPTWVDAIQALDVQLGVSVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRIDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG
Download Length: 792 bp
>AT199958 NZ_CP097670:354436-354735 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1L5JQJ1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0M0HVB9 |