Detailed information of TA system TA199957

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 1113556..1115303
• Replicon: chromosome
• Accession: NZ_CP073630
• Organism: Proteus terrae subsp. cibarius strain S24-2-1

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: KEF19_RS05165
• Protein ID: WP_098941872.1
• Coordinates: 1113930..1115303 (-)
• Length: 458 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: KEF19_RS05160
• Protein ID: WP_098941871.1
• Coordinates: 1113556..1113933 (-)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KEF19_RS05135	1109456..1111189	+	1734	WP_075673441.1	hydrogenase large subunit	-
KEF19_RS05140	1111201..1111755	+	555	WP_075673442.1	hydrogenase 4 subunit H	-
KEF19_RS05145	1111752..1112516	+	765	WP_211838165.1	NADH-quinone oxidoreductase subunit B family protein	-
KEF19_RS05150	1112527..1112937	+	411	WP_088494545.1	formate hydrogenlyase maturation HycH family protein	-
KEF19_RS05155	1112934..1113434	+	501	WP_075673444.1	hydrogenase maturation peptidase HycI	-
KEF19_RS05160	1113556..1113933	-	378	WP_098941871.1	helix-turn-helix transcriptional regulator	Antitoxin
KEF19_RS05165	1113930..1115303	-	1374	WP_098941872.1	HipA domain-containing protein	Toxin
KEF19_RS05170	1115686..1116675	+	990	WP_156734136.1	glycosyltransferase	-
KEF19_RS05175	1117080..1118663	+	1584	WP_156734135.1	ABC transporter substrate-binding protein	-
KEF19_RS05180	1118648..1119631	+	984	WP_075673449.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (174-418)

Antitoxin

• Cro/C1-type helix-turn-helix domain (48-103)

Sequences

Toxin

Protein

• Length: 458 a.a.
• Molecular weight: 52589.44 Da
• Isoelectric Point: 4.6415

>T199957 WP_098941872.1 NZ_CP073630:c1115303-1113930 [Proteus terrae subsp. cibarius]
MEKITLQAFLNQEWVDIAIINFPKYDRMLYASKYDITYPITELEYETSYSIEHLYQDDQHAVSINHPVELYFDDSGSPGW
LKFLDDIVPSGASRRYWLQYLDIAELSTEQQNYELLHHGTISPIGNLRVKESLPAPSPLNRNLFFTINDVKNRASDFLDY
AQRKGAAAGGATGAGGEAPKLLLRCNDNEEVWIDTYQDDISNLDKYYLVKFPRGSRSVVDCNILRTEYHFYHELTDMGFD
TIPIKDMRLEEGDNYPSLWLPRFDIKIENNKIIRLAMESVYSILNKAPGTTLYHETVIKELIDKINQSNMVTEFGFQFNT
ANFIIEWVRRDLLNIIFGNSDNHGRNTSLIRYNNAIYLAPIYDFAPMKADPEGIARTTKWGSHSEIGGEYNFINIADSLS
DLIAPEQLLNALQETAQQLLTLKERLEMRGVPTQILTMPSFGFDFIPNKLERWGLLP

Nucleotide

• Length: 1374 bp

>T199957 NZ_CP097670:328118-328486 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 14108.43 Da
• Isoelectric Point: 10.5220

>AT199957 WP_098941871.1 NZ_CP073630:c1113933-1113556 [Proteus terrae subsp. cibarius]
MNNVENKNHIDKFPTRASRKHQFVATTDRKQVISKIMAHLLFGEITQGEALKMLRIKVLGLNQDLYAKLINVSRKTLSEI
ENDRGNYSADIINKVFKPFGLKVGLVPSSPHILSSLLKESPPINE

Nucleotide

• Length: 378 bp

>AT199957 NZ_CP097670:327900-328121 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA